ArticleAmerican journal of respiratory and critical care medicine2020
Platelet Extracellular Vesicles Drive Inflammasome-IL-1β-Dependent Lung Injury in Sickle Cell Disease.
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Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 92 citations in OpenAlex.
- Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial.The Lancet. Haematology · 2024Trial
- Platelets in sickle cell disease: biomarkers, mediators, and lessons from clinical trials.Blood vessels, thrombosis & hemostasis · 2026Review
- Activation of Platelet Caspase-1 and P-Selectin Over-Expression in Sickle Cell Disease Patients: An Involvement of NLRP3 Inflammasome?Journal of cellular and molecular medicine · 2026Article
- Haemolytic injury and cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Thrombocytosis and the generation of platelet-derived microparticles in the pathophysiology of sickle cell disease.British journal of haematology · 2026Review
- Acute therapy with hemopexin (CSL889) resolves LPS-induced lung vaso-occlusion in sickle mice.Blood vessels, thrombosis & hemostasis · 2026Article
- Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities.Comprehensive Physiology · 2026Review
- Microfluidics for Blood Disorders and Hematological Disease Monitoring and Modeling.International journal of molecular sciences · 2026Review
- Review
- NLRP3 inflammasome-mediated platelet hyperreactivity in sickle cell mice is targetable by BTK inhibition.Biochemical and biophysical research communications · 2026Article
- Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria.Blood advances · 2026Article
- CD39 polymorphism enables lung thrombosis in sickle cell disease.Nature communications · 2026Article
- The emerging roles of platelet-derived extracellular vesicles in disease.Annals of medicine · 2025Review
- αIIbβ3-dependent platelet procoagulant activity promotes pulmonary arterial thrombosis triggered by circulating tissue factor.Thrombosis research · 2025Article
- crizanlizumab and inclacumab are equally potent inhibitors of cell adhesion in the blood of patients with sickle cell disease.Blood. Red cells & iron · 2025Article
- Ten-Year Longitudinal Study Clarifies Impact of Hemolysis and Pulmonary Hypertension on Patients with Sickle Cell Anemia.American journal of respiratory and critical care medicine · 2025Article
- Emerging pathways in thromboinflammation of sickle cell disease: novel findings in disease pathogenesis.Research and practice in thrombosis and haemostasis · 2025Review
- An update on extracellular vesicles in hematologic disorders: molecular mediators, clinical biomarkers, and emerging therapeutics.Molecular biology reports · 2025Review
- Review
- Crosstalk between lung and extrapulmonary organs in sepsis-related acute lung injury/acute respiratory distress syndrome.Annals of intensive care · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Ravi VatsPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Tomasz BrzoskaPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Margaret F BennewitzPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Maritza A JimenezPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Tirthadipa Pradhan-SunddDivision of Experimental Pathology.
Egemen TutuncuogluPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Jude JonassaintPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Edgar GutierrezDepartment of Physics, University of California San Diego, La Jolla, California.
Simon C WatkinsCenter for Biologic Imaging.
Sruti ShivaPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Melanie J ScottDepartment of Surgery.
Adrian E MorelliThomas E. Starzl Transplantation Institute, and.
Matthew D NealDepartment of Surgery.
Gregory J KatoPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Mark T GladwinPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.
Prithu SunddPittsburgh Heart, Lung, and Blood Vascular Medicine Institute.ORCID 0000-0001-7568-5719
University of Pittsburgh · USNational Heart Lung and Blood Institute · USBiolog (United States) · USPalmetto Hematology Oncology · USUniversity of California San Diego · USWest Virginia University · US
Funding
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0MPulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest SyndromeR01HL128297 · NHLBI · VERSITI WISCONSIN, INC. · PI SUNDD, PRITHU · 2015 to 2025
$5.4MTranslational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0MInflammasome activation in trauma-hemorrhagic shockR01GM102146 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCOTT, MELANIE J. · 2013 to 2025
$4.3MMechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9MMechanisms of platelet exosome-mediated acute chest syndrome in sickle cell diseaseR01HL141080 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D, NOVELLI, ENRICO M · 2019 to 2022
$3.1MHeme-induced platelet mtROS drives TSP1 release to accelerate PH pathogenesisR01HL133003 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIVA, SRUTI · 2017 to 2020
$1.6MRequest for Zeiss 710 multiphoton 5Live Duoscan MicroscopeS10RR028478 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2011 to 2011
$1.1MRequest for a Nikon A1R Multiphoton MicroscopeS10OD025041 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2018 to 2018
$870kMolecular Mechanism of Sickle Cell Hepatic CrisisK01DK125617 · NIDDK · VERSITI WISCONSIN, INC. · PI PRADHAN-SUNDD, TIRTHADIPA · 2020 to 2024
$736kPulmonary arteriole micro-embolism by platelet-neutrophil aggregates promotes sickle cell disease acute chest syndromeF32HL131216 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENNEWITZ, MARGARET · 2016 to 2016
$38kNCRR NIH HHS S10 RR028478NHLBI NIH HHS F32 HL131216NHLBI NIH HHS R01 HL128297NHLBI NIH HHS R01 HL133003NHLBI NIH HHS R01 HL141080NHLBI NIH HHS T32 HL076124NHLBI NIH HHS T32 HL110849NIDDK NIH HHS K01 DK125617NIGMS NIH HHS R01 GM102146NIGMS NIH HHS R35 GM119526NIH HHS S10 OD025041
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acute Chest SyndromeAnemia, Sickle CellAnimalsExtracellular VesiclesHumansInflammasomesLung InjuryMiceMice, TransgenicModels, AnimalNeutrophilsPlatelet AggregationInflammasomesacute chest syndromeneutrophil–platelet aggregatesvasoocclusion
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.