Evidence map›Paper›PMID 31498454›Full record

ArticleThe Laryngoscope2020

Office-based CO

David J Wellenstein, Jimmie Honings, Anouk S Schimberg, Henrieke W Schutte, Jasmijn M Herruer, Frank J A van den Hoogen, Robert P Takes, Guido B van den Broek

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06703515 (Randomized Controlled Trial of Awake Transnasal Laser-assisted Surgery), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06703515 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Trial of Awake Transnasal Laser-assisted Surgery (TNLS) and Microlaryngeal Surgery for Vocal Cord Cyst

TypeinterventionalSponsorChinese University of Hong KongRan2024 to 2027Enrolled54ConditionsVocal Cord CystArmsAwake transnasal laser-assisted surgery (TNLS), Microlaryngeal surgery (MLS)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Systematic Review: Effectiveness of Carbon Dioxide Lasers for Treatment of Adult Laryngeal Hemangioma.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
  2. Management of Vocal Fold Leukoplakia.World journal of otorhinolaryngology - head and neck surgery · 2025
    Article
  3. Article
  4. Comparing KTP and COLaryngoscope investigative otolaryngology · 2022
    Review
  5. Review
  6. On the Merits of Using Angled Fiber Tips in Office-based Laser Surgery of the Vocal Folds.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

David J WellensteinDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-8437-5664
Jimmie HoningsDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Anouk S SchimbergDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Henrieke W SchutteDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-9902-8131
Jasmijn M HerruerDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Frank J A van den HoogenDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Robert P TakesDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Guido B van den BroekDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients with laryngeal pathology are often treated with CO

methodsA prospective cohort study was performed of 30 consecutive procedures. Inclusion started in June 2016 and was completed in August 2018. Adult patients with clinically benign or premalignant laryngeal lesions who could not undergo transoral laser microsurgery in the operating room under general anesthesia were included. Reasons were either contraindications for general anesthesia, previously failed therapeutic laryngoscopy under general anesthesia, and preference of a procedure under topical anesthesia by the patient. The mean follow-up was 9 months.

resultsThirty procedures were performed in 27 patients (24 males) with an average age of 62 years. Twenty-nine (97%) procedures were fully completed without complications. The mean preoperative Voice Handicap Index (VHI) score (VHI 44) significantly decreased 2 months (VHI 28, P = 0.032) and 6 months (VHI 14, P < 0.001) after the procedure. Almost two-thirds of patients showed no residual or recurrent disease at their follow-up visits.

conclusionOffice-based CO LEVEL OF EVIDENCE: 2 Laryngoscope, 130:1503-1507, 2020.

Indexed as

Ambulatory Surgical ProceduresFeasibility StudiesFemaleHumansLaryngeal DiseasesLasers, GasMaleMiddle AgedPrecancerous ConditionsProspective StudiesCO2 laserlarynxLaser surgeryoffice-basedtopical anesthesia

Identifiers

PMID31498454
PMCPMC7318140
OpenAlexW2972678697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.