ArticleJournal of the National Cancer Institute2020
Trajectories of Cognitive Function Prior to Cancer Diagnosis: A Population-Based Study.
Article in Journal of the National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prevalence of cognitive impairment and change in patients with breast cancer: A systematic review of longitudinal studies.Psycho-oncology · 2021Pooled it
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- Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study.Frontiers in aging neuroscience · 2025Article
- Education, incident cancer, and rate of memory decline in a national sample of US adults in mid-to-later-life.Journal of geriatric oncology · 2023Article
- Cognitive adverse effects of chemotherapy and immunotherapy: are interventions within reach?Nature reviews. Neurology · 2022Review
- Understanding Longitudinal Changes in Cognitive Function in Lymphoma Patients: Where to Next?Journal of the National Cancer Institute · 2022Article
- Protective Effects ofJNCI cancer spectrum · 2021Article
- Understanding the Time Course of Cancer-Associated Cognitive Decline: Does Impairment Precede Diagnosis?Journal of the National Cancer Institute · 2020Article
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
- Brain structure prior to non-central nervous system cancer diagnosis: A population-based cohort study.NeuroImage. Clinical · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAn emerging body of research suggests that noncentral nervous system cancer may negatively impact the brain apart from effects of cancer treatment. However, studies assessing cognitive function in newly diagnosed cancer patients cannot exclude selection bias and psychological effects of cancer diagnosis. To overcome these limitations, we investigated trajectories of cognitive function of patients before cancer diagnosis.
methodsBetween 1989 and 2013, a total of 2059 participants from the population-based Rotterdam Study were diagnosed with noncentral nervous system cancer. Cognitive assessments were performed every 3 to 5 years using a neuropsychological battery. The general cognitive factor was composed of individual cognitive tests to assess global cognition. Using linear mixed models, we compared change in cognitive function of cancer case patients before diagnosis with cognitive change of age-matched cancer-free control subjects (1:2). In addition, we performed sensitivity analyses by discarding assessments of control subjects 5 years before the end of follow-up to exclude effects from potential undiagnosed cancer. All statistical tests were two-sided.
resultsThe Word Learning Test immediate recall declined faster among case patients than among control subjects (-0.05, 95% confidence interval = -0.09 to -0.01 vs 0.01, 95% confidence interval = -0.01 to 0.03; P for difference = .003). However, this difference was not statistically significant in sensitivity analyses. Furthermore, no statistically significant differences were observed in change of other individual cognitive tests and of the general cognitive factor.
conclusionsIn this study, we evaluated cognitive function in a large group of cancer patients prior to diagnosis, thereby excluding the psychological impact of cancer diagnosis and biased patient selection. In contrast to previous studies shortly after cancer diagnosis, we found no difference in change of cognitive function between cancer patients and control subjects.
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