Evidence map›Paper›PMID 31498125›Full record

Trial reportJournal of Alzheimer's disease : JAD2019

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.

Aurélie Ledreux, Krister Håkansson, Roger Carlsson, Mhretab Kidane, Laura Columbo, Yvonne Terjestam, Eliza Ryan, Erich Tusch, Bengt Winblad, Kirk Daffner and 2 more

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05128396 naactive not recruitingnot on this map

Successful Aging and Enrichment (SAGE): Effects of Environmental Stimulation on Cognitive Health and Neuroplasticity

TypeinterventionalSponsorBrigham and Women's HospitalRan2013 to 2026Enrolled72ConditionsCognitive Health, Healthy AgingArmsCognitive Stimulation, Mindfulness training, Physical Activity, Control Group
NCT06130735 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Computerized Cognitive Training: Characterization of Factors That Predict Cognitive Enhancement in Acquired Brain Injury

TypeinterventionalSponsorBrigham and Women's HospitalRan2023 to 2026Enrolled30ConditionsAcquired Brain Injury, Mild Cognitive Impairment, Mild Neurocognitive DisorderArmsCognitive Computerized Training
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  6. SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  7. Article
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  16. Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
  17. Article
  18. Article
  19. Cognitive Training Effect and Imaging Evidence.Advances in experimental medicine and biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Aurélie LedreuxKnoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
Krister HåkanssonTheme Aging, Karolinska University Hospital, Stockholm, Sweden.
Roger CarlssonDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Mhretab KidaneDepartment of Computer Science and Media Technology, Linnaeus University, Växjö, Sweden.
Laura ColumboDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
Yvonne TerjestamDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Eliza RyanDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Erich TuschDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bengt WinbladDepartment of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Kirk DaffnerDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ann-Charlotte GranholmKnoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA.
Abdul Kadir H MohammedDepartment of Psychology, Linnaeus University, Växjö, Sweden.
Karolinska Institutet · SELinnaeus University · SEHarvard University · USUniversity of Denver · USBrigham and Women's Hospital · USMedical University of South Carolina · US

Funding

Exosome biology in Alzheimer's disease and concussion.R01AG071228 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, LEDREUX, AURELIE · 2021 to 2025
$3.1M
MECHANISMS OF NGF-INDUCED COGNITIVE IMPROVEMENT IN AGINGR01AG010755 · NIA · UNIVERSITY OF COLORADO DENVER · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 1991 to 2007
$2.0M
NIA NIH HHS R01 AG010755NIA NIH HHS R01 AG071228
6 · The paper itself

Abstract

Previous studies have indicated that an active lifestyle is associated with better brain health and a longer life, compared to a more sedentary lifestyle. These studies, both on human and animal subjects, have typically focused on a single activity, usually physical exercise, but other activities have received an increasing interest. One proposed mechanism is that physical exercise increases levels of brain-derived neurotrophic factor (BDNF) in the brain. For the first time, the long-term effects on serum BDNF levels were compared in persons who engaged in either physical exercise training, cognitive training, or mindfulness practice during 5 weeks, and compared with an active control group. Two cohorts of healthy older individuals, one from the Boston area in the US and one from the Växjö area in Sweden, participated. A total of 146 participants were randomly assigned to one of the four groups. All interventions were structurally similar, using interactive, computer-based software that directed participants to carry out specified activities for 35 minutes/day, 5 days per week for 5 weeks. Blood samples were obtained at baseline and soon after the completion of the 5-week long intervention program, and serum BDNF levels were measured using a commercially available ELISA. Only the group that underwent cognitive training increased their serum BDNF levels after 5 weeks of training (F1,74 = 4.22, p = 0.044, partial η2 = 0.054), corresponding to an average 10% increase. These results strongly suggest that cognitive training can exert beneficial effects on brain health in an older adult population.

Indexed as

Healthy AgingAgedBrain-Derived Neurotrophic FactorCognitionCorrelation of DataExerciseFemaleHealthy LifestyleHumansLearningMaleMindfulnessNeuropsychological TestsOutcome Assessment, Health CareBrain-Derived Neurotrophic FactorAgingbrain-derived neurotrophic factorcognitive trainingmindfulnessphysical exercise

Identifiers

PMID31498125
PMCPMC10896591
OpenAlexW2971648152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.