Evidence map›Paper›PMID 31497876›Full record

ArticleThe International journal of eating disorders2020

Examining sex as a predictor and moderator of treatment outcomes for binge-eating disorder: Analysis of aggregated randomized controlled trials.

Janet A Lydecker, Ralitza Gueorguieva, Robin Masheb, Marney A White, Carlos M Grilo

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Janet A LydeckerDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0001-6425-514X
Ralitza GueorguievaDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Robin MashebDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0002-6799-6012
Marney A WhiteDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Carlos M GriloDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0003-0245-3444
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Treatment of Obesity and Binge Eating: Behavioral weight Loss versus Stepped CareR01DK049587 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2002 to 2020
$8.5M
Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating DisorderR01DK112771 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M, MCKEE, SHERRY ANN · 2017 to 2021
$3.6M
Cognitive-Behavioral and Pharmacologic Treatment of Binge Eating DisorderR01DK114075 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2018 to 2022
$3.6M
Mid-Career Investigator Award in Eating and WeightK24DK070052 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2005 to 2015
$1.4M
Development and Initial Efficacy Testing of a Cognitive-Behavioral Intervention to Treat Adolescent Binge EatingK23DK115893 · NIDDK · YALE UNIVERSITY · PI LYDECKER, JANET A · 2019 to 2023
$1.1M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K23 DK115893NIDDK NIH HHS K24 DK070052NIDDK NIH HHS R01 DK049587NIDDK NIH HHS R01 DK112771NIDDK NIH HHS R01 DK114075
6 · The paper itself

Abstract

objectiveThis study examined whether sex predicted and/or moderated treatment outcomes among men and women who participated in binge-eating disorder (BED) randomized controlled trials (RCTs).

methodData were aggregated from RCTs performed at one medical center. RCTs tested cognitive-behavioral therapy, behavioral weight loss, multimodal treatment, and/or control conditions. Participants were 660 adults, both men (n = 170) and women (n = 490), with Diagnostic and Statistical Manual-fourth edition (DSM-IV)-defined BED. Doctoral-level research-clinicians assessed participants using structured interviews and established self-report measures of eating-disorder psychopathology and depression, and measured height and weight. Assessments occurred at baseline, throughout treatment, and at post-treatment.

resultsSex was not a significant moderator of any treatment outcomes. Mixed models revealed sex had a main effect: men had lower eating-disorder psychopathology and lost more weight than women over the course of treatment. DISCUSSION: Both epidemiological and RCT studies report disparities in treatment-seeking between men and women with BED. Despite this, men have comparable or better treatment outcomes compared with women, including significantly greater weight loss. Thus, disseminating evidence-based BED treatments is promising for both men and women. Additional research is necessary, however, to understand treatment effects-including other predictors and moderators of outcomes-across diverse providers, treatment settings, and patient groups.

Indexed as

Binge-Eating DisorderFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSex FactorsTreatment Outcomebehavioral weight lossbinge-eating disordercognitive-behavioral therapygenderpsychotherapysextreatment

Identifiers

PMID31497876
PMCPMC6983351
OpenAlexW2972527655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.