ArticleAmerican journal of epidemiology2019
Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.
Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Early life factors, blood pressure percentile trajectories, and elevated blood pressure in children.Pediatric research · 2026Article
- Subclinical Changes in Cardiovascular Function During the Neonatal Period in Infants Born to Mothers With Diabetes.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Prenatal Per- and Polyfluoroalkyl Substance Exposures and Longitudinal Blood Pressure Measurements in Children Aged 3 to 18 Years: Findings From a Racially and Ethnically Diverse US Birth Cohort.Journal of the American Heart Association · 2025Article
- Prenatal and Perinatal Factors of Life's Essential 8 Cardiovascular Health Trajectories.JAMA network open · 2025Article
- Blood pressure in young Aboriginal and Torres Strait Islander people: analysis of baseline data from a prospective cohort study.The Medical journal of Australia · 2025Article
- Tracking of blood pressure levels from childhood.Pediatric nephrology (Berlin, Germany) · 2025Review
- Placental Pathology and Blood Pressure at Age 7: A Longitudinal Discordant Twin Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study.Journal of the American Heart Association · 2024Article
- Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024Article
- Prevalence of and Factors Associated With High Blood Pressure at 15 Years of Age: A Birth Cohort Study.Journal of the American Heart Association · 2023Article
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Critical windows of perinatal particulate matter (PMEnvironmental research · 2022Article
- Maternal body mass index, offspring body mass index, and blood pressure at 18 years: a causal mediation analysis.International journal of obesity (2005) · 2021Article
- Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Prenatal PM2.5 exposure in the second and third trimesters predicts neurocognitive performance at age 9-10 years: A cohort study of Mexico City children.Environmental research · 2021Article
- Low-level exposure to lead, mercury, arsenic, and cadmium, and blood pressure among 8-17-year-old participants of the 2009-2016 National Health and Nutrition Examination Survey.Environmental research · 2021Article
- Blood Pressure Trajectories Across the Life Course.American journal of hypertension · 2021Article
- Hypertension in Children and Adolescents with Turner Syndrome (TS), Neurofibromatosis 1 (NF1), and Williams Syndrome (WS).Current hypertension reports · 2021Review
- Identifying critical windows of prenatal particulate matter (PMEnvironmental research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Childhood blood pressure (BP) is a strong predictor of later risk of cardiovascular disease. However, few studies have assessed dynamic BP trajectories throughout the early-life period. We investigated the relationship between early-life factors and systolic BP (SBP) from infancy to adolescence using linear spline mixed-effects models among 1,370 children from Project Viva, a Boston, Massachusetts-area cohort recruited in 1999-2002. After adjusting for confounders and child height, we observed higher SBP in children exposed to gestational diabetes mellitus (vs. normoglycemia; age 3 years: β = 3.16 mm Hg (95% confidence interval (CI): 0.28, 6.04); age 6 years: β = 1.83 mm Hg (95% CI: 0.06, 3.60)), hypertensive disorders of pregnancy (vs. normal maternal BP; age 6 years: β = 1.39 mm Hg (95% CI: 0.10, 2.67); age 9 years: β = 1.84 mm Hg (95% CI: 0.34, 3.34); age 12 years: β = 1.70 mm Hg (95% CI: 0.48, 2.92)), higher neonatal SBP (per 10-mm Hg increase; age 3 years: β = 1.26 mm Hg (95% CI: 0.42, 2.09); age 6 years: β = 1.00 mm Hg (95% CI: 0.49, 1.51); age 9 years: β = 0.75 mm Hg (95% CI: 0.17, 1.33)), and formula milk in the first 6 months of life (vs. breast milk only; age 12 years: β = 2.10 mm Hg (95% CI: 0.46, 3.74); age 15 years: β = 3.52 mm Hg (95% CI: 1.40, 5.64); age 18 years: β = 4.94 mm Hg (95% CI: 1.88, 7.99)). Our findings provide evidence of programming of offspring SBP trajectories by gestational diabetes, hypertensive disorders of pregnancy, and formula milk intake and of neonatal BP being a potentially useful marker of childhood BP. These factors could be relevant in identifying children who are at risk of developing elevated BP.
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