ArticleAdvances in geriatric medicine and research2019
The Aging Brain & the Dorsal Basal Ganglia: Implications for Age-Related Limitations of Mobility.
Article in Advances in geriatric medicine and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Incidentally Detected Basal Ganglia Calcifications Are Not Associated with Impaired Mobility and Recurrent Falls in Older Adults.Journal of clinical medicine · 2026Article
- Slowing of Movements in Healthy Aging as a Rational Economic Response to an Elevated Effort Landscape.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Learned Irrelevance, Perseveration, and Cognitive Aging: A Cross-Sectional Study of Cognitively Unimpaired Older Adults.Brain sciences · 2023Article
- Article
- Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging.Biomedicines · 2022Review
- Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes.Aging cell · 2022Article
- Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM.Journal of rehabilitation medicine · 2021Article
- Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Deterioration, Compensation and Motor Control Processes in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2021Review
- Increased Likelihood of Falling in Older Cannabis Users vs. Non-Users.Brain sciences · 2021Article
- Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats.Frontiers in aging neuroscience · 2021Article
- [Correlation between sarcopenia and albuminuria in patients with type 2 diabetes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Corticospinal Control of Human Locomotion as a New Determinant of Age-Related Sarcopenia: An Exploratory Study.Journal of clinical medicine · 2020Article
- A Narrative Review of Handgrip Strength and Cognitive Functioning: Bringing a New Characteristic to Muscle Memory.Journal of Alzheimer's disease : JAD · 2020Review
- Mobility in Older Community-Dwelling Persons: A Narrative Review.Frontiers in physiology · 2020Review
- Brain predicted age difference mediates pain impact on physical performance in community dwelling middle to older aged adults.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The capacity to move is essential for independence and declines with age. Limitations in mobility impact ~35% of adults over 70 and the majority of adults over 85. These limitations are highly associated with disability, dependency, and survival. More than 25-years ago the term "sarcopenia" was coined to highlight the age-related loss of muscle mass and strength with the assumption being that sarcopenia led to limitations in mobility. However, contrary to expectations, recent findings clearly indicate these variables only modestly explain limitations in mobility. One likely reason the current sarcopenia variables of muscle mass and strength do not discriminate, or predict, mobility limitations well is because they are heavily influenced by musculoskeletal mechanisms and do not incorporate measures reflective of the central neural control of mobility. Unfortunately, the precise central neural changes associated with aging that lead to decreased mobility are poorly understood. This knowledge gap has hampered the development of effective interventions for mobility limitations and the subsequent reduction of major functional disability for older adults. Here, we discuss the potential role of the motor control circuit of the dorsal basal ganglia as well as dopaminergic function in age-related reductions in mobility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.