ReviewAmerican journal of cancer research2019
Focus on exosomes: novel pathogenic components of leukemia.
Review in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Engineered small extracellular vesicles in hematologic malignancies: mechanisms, therapeutic strategies, and translational challenges.Clinical and experimental medicine · 2026Review
- Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies.Stem cell research & therapy · 2025Review
- Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review.Cancers · 2024Review
- A novel therapeutic strategy: the significance of exosomal miRNAs in acute myeloid leukemia.Medical oncology (Northwood, London, England) · 2024Review
- Review
- CD34Frontiers in cell and developmental biology · 2023Article
- Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors.Molecules (Basel, Switzerland) · 2022Review
- Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia.Molecular cancer · 2022Article
- Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Review
- Paediatric pre-B acute lymphoblastic leukaemia-derived exosomes regulate immune function in human T cells.Journal of cellular and molecular medicine · 2022Article
- HucMSC exosomes promoted imatinib-induced apoptosis in K562-R cells via a miR-145a-5p/USP6/GLS1 axis.Cell death & disease · 2022Article
- AZD9291-resistant non-small cell lung cancer cell-derived exosomal lnc-MZT2A-5:1 induces the activation of fibroblasts.Annals of translational medicine · 2021Article
- Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4.Cell death discovery · 2021Article
- Acute lymphoblastic leukemia-derived exosome inhibits cytotoxicity of natural killer cells by TGF-β signaling pathway.3 Biotech · 2021Article
- Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury.Current neuropharmacology · 2021Review
- AML-derived Extracellular Vesicles ConferIranian journal of pharmaceutical research : IJPR · 2021Article
- Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment.Frontiers in immunology · 2021Review
- The Role of Exosomes in Stemness and Neurodegenerative Diseases-Chemoresistant-Cancer Therapeutics and Phytochemicals.International journal of molecular sciences · 2020Review
- Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring.Pharmaceuticals (Basel, Switzerland) · 2020Review
- The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes are released membrane vesicles derived from late endosomes, which share structural and biochemical characteristics with proteasomes. Exosomes are responsible for trafficking proteins, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) among cells and regulating various cellular processes, such as differentiation, proliferation, migration, invasion, and apoptosis. Although our knowledge of the roles of exosomes in the initiation and progression of leukemia is limited, some studies have indicated that exosomes can encompass many functional factors with an appropriate sorting signal, thereby supporting the metastasis, drug resistance, and immune escape of leukemia cells. This review initially focuses on the biogenesis and composition of exosomes and then summarizes the application of exosomes as a screening biomarker and a potential therapeutic target in leukemia. Many recent reports on the functions of exosomes released from leukemia cells are also discussed, including drug resistance, immune dysfunction, and microenvironment manipulation. Given the critical roles of exosomes in leukemia, understanding the mechanisms regulating the compositions and levels of exosomes, as well as defining exosome functions, will ultimately provide additional insights into the use of exosomes as therapeutic agents for leukemia treatment.
Indexed as
Identifiers
31497361PMC6726990W2985314663What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.