ArticleAmerican journal of cancer research2019
The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression.
Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Integrated proteomic, transcriptomic, and epigenomic profiling identifies SRA1 as a novel therapeutic target for postpartum depression.Npj mental health research · 2026Article
- The impact of breast cancer on social cognition in female Colombian patients.BMC psychology · 2022Article
- Alterations in degree centrality and cognitive function in breast cancer patients after chemotherapy.Brain imaging and behavior · 2022Article
- Dynamic functional network connectivity reveals the brain functional alterations in lung cancer patients after chemotherapy.Brain imaging and behavior · 2022Article
- Altered Regional Brain Glucose Metabolism in Diffuse Large B-Cell Lymphoma Patients Treated With Cyclophosphamide, Epirubicin, Vincristine, and Prednisone: An Fluorodeoxyglucose Positron Emission Tomography Study of 205 Cases.Frontiers in neuroscience · 2022Article
- COMT rs737865 mediates chemobrain in breast cancer patients with various levels of Ki-67.American journal of cancer research · 2022Article
- Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy.Scientific reports · 2021Article
- Connectivity of the Cerebello-Thalamo-Cortical Pathway in Survivors of Childhood Leukemia Treated With Chemotherapy Only.JAMA network open · 2020Article
- Network-level functional connectivity alterations in chemotherapy treated breast cancer patients: a longitudinal resting state functional MRI study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2020Article
- Changes in plasma IL-1β, TNF-α and IL-4 levels are involved in chemotherapy-related cognitive impairment in early-stage breast cancer patients.American journal of translational research · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate chemotherapy-related cognitive impairment (CRCI) in breast cancer patients with different hormone receptor (HR) expression and its neural mechanisms, forty BC patient were enrolled in this study and were divided into two groups. HR+ group was composed of twenty-one patients with Estrogen Receptor (ER)+/Progesterone Receptor (PR) +, HR- group included nineteen patients with ER-/PR-. A battery of neuropsychological tests and resting-state functional magnetic resonance imaging (rs-fMRI) examinations were administered to all subjects. The functional connectivity of the dorsolateral prefrontal cortex (DLPFC) of the patients was calculated from the resting-state fMRI data, and the correlation between the DLPFC's connectivity and the neuropsychological test was analyzed. The functional connectivity (FC) of the left dorsolateral prefrontal cortex (DLPFC) with the left precuneus (PCU), the right DLPFC with the right precuneus and the right superior frontal gyrus (SFG) of the HR- group were significantly increased compared to the HR+ group. Meanwhile, a significant positive correlation was found between the post-chemotherapy prospective memory (PM) score and the functional connectivity of the left DLPFC with the left precuneus in the HR- group. These findings suggest that different hormone receptor expression in patients with breast cancer may be associated with CRCI and provide evidence that the DLPFC functional connectivity (FC) strength may be selectively involved in CRCI in HR- group breast cancer patients, especially in regard to the subjective prospective memory.
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31497358PMC6726991W2984773497What OpenQuestion holds
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