ArticleAmerican journal of translational research2019
Suitability of the use of an elastin matrix combined with bone morphogenetic protein for the repair of cranial defects.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Treatment of femoral defects in rats with collagen and elastin polymers combined with hydroxyapatite and bone morphogenetic protein.Frontiers in bioengineering and biotechnology · 2026Article
- Plasma-rich fibrin gel and adipose-derived allogeneic mesenchymal stem cells: innovation in the treatment of second-degree deep burn wound; characterization and in-vivo study.Cell and tissue banking · 2025Article
- Use of Plant Extracts in Polymeric Scaffolds in the Regeneration of Mandibular Injuries.Pharmaceutics · 2024Article
- Bioactive Scaffolds as a Promising Alternative for Enhancing Critical-Size Bone Defect Regeneration in the Craniomaxillofacial Region.ACS applied bio materials · 2023Review
- Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy.International journal of molecular sciences · 2023Article
- In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair.Journal of functional biomaterials · 2023Article
- Article
- In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats.Polymers · 2022Article
- Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing.Pharmaceutics · 2021Article
- In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process.Molecules (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of biomaterials in medical and dental areas has become increasingly important due to the need to restore areas with bone loss or defects. This study analyzed the use of a new elastin polymer matrix combined with Bone Morphogenetic Protein for the repair of cranial defects in rats. Thirty rats were divided into five groups: control (C) defect without graft, E24 (defect filled with elastin matrix submitted to alkaline hydrolysis at 50°C for 24 h), E24/BMP (defect filled with elastin matrix treated at 50°C for 24 h plus BMP), E96 (defect filled with elastin matrix treated at 37°C for 96 h) and E96/BMP (defect filled with elastin matrix treated at 37°C for 96 h plus BMP). The animals were killed after 6 weeks. In the histological and microtomographic analysis, all groups showed bone growth from the defect margins remaining in this region without a marked inflammatory process, but in the E96/BMP group the lamellae were thicker and the collagen fibers more organized. Histometrically, the same group presented higher percentage of new formation (43.25 ± 3.72) in relation to the other groups. It was concluded that the support and delivery system formed by the elastin matrix associated with BMPs had a positive effect on the bone repair process.
Indexed as
Identifiers
31497239PMC6731398What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.