ArticleAmerican journal of translational research2019
Smad signaling coincides with epithelial-mesenchymal transition in a rat model of intrauterine adhesion.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Vitamin D receptor loss promotes endometrial fibrosis via autophagy-mediated epithelial-mesenchymal transition.Genes & diseases · 2026Article
- Human embryonic stem cell-derived immunity-and-matrix-regulatory cells promote endometrial repair and fertility restoration in IUA rats.Stem cell research & therapy · 2025Article
- Innovative therapeutic strategies for intrauterine adhesions: Role of umbilical cord mesenchymal stem cells in rat models.Experimental and therapeutic medicine · 2025Article
- LncRNA MALAT1 Knockdown Alleviates Fibrogenic Response in Human Endometrial Stromal Cells Via the miR-22-3p/TGFβR1/Smad2/3 Pathway.Cell biochemistry and biophysics · 2024Article
- Extracellular Vesicles Derived from Mesenchymal Stem Cells as Cell-Free Therapy for Intrauterine Adhesion.International journal of stem cells · 2023Review
- Dulaglutide Ameliorates Intrauterine Adhesion by Suppressing Inflammation and Epithelial-Mesenchymal Transition via Inhibiting the TGF-β/Smad2 Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Evaluation of different rat models intrauterine adhesion models and improvement of the technique for their establishment.Experimental animals · 2023Article
- Assessment ofInternational journal of molecular sciences · 2023Article
- Mycobiome Dysbiosis in Women with Intrauterine Adhesions.Microbiology spectrum · 2022Article
- Association of Intrauterine Microbes with Endometrial Factors in Intrauterine Adhesion Formation and after Medicine Treatment.Pathogens (Basel, Switzerland) · 2022Article
- Human amniotic mesenchymal stem cells combined with PPCNg facilitate injured endometrial regeneration.Stem cell research & therapy · 2022Article
- EndMT: New findings on the origin of myofibroblasts in endometrial fibrosis of intrauterine adhesions.Reproductive biology and endocrinology : RB&E · 2022Article
- Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarizationFrontiers in immunology · 2022Article
- Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury.Stem cell research & therapy · 2021Review
- Pathogenesis of Endometriosis: New Insights into Prospective Therapies.International journal of molecular sciences · 2021Review
- Article
- Recent Advances in Understandings Towards Pathogenesis and Treatment for Intrauterine Adhesion and Disruptive Insights from Single-Cell Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision.International journal of molecular sciences · 2021Review
- Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation.Stem cell research & therapy · 2021Article
- MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways.Pathology oncology research : POR · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntrauterine adhesion (IUA) is a fibrotic disease mainly caused by tissue injury, yet the mechanism is poorly understood. The aim of this study was to investigate the roles of TGF-β1/BMP7/Smad signaling coincident with epithelial-mesenchymal transition (EMT) in IUA.
methodsTwenty-four female SD rats were divided into IUA and sham groups. For each animal, a mechanical injury or sham operation was performed on the left uterus (IUA-L, Sham-L), and the right uterus (IUA-R, Sham-R) was used as the control. Animals were sacrificed in batches on days 7 and 28. The endometrial morphology, number of endometrial glands, microvascular density (MVD), area of endometrial fibrosis and immunohistochemistry (IHC) analysis of biomarkers of EMT, as well as levels of TGF-β1, phosphorylated Smad3 (pSmad3), BMP7, phosphorylated Smad1/5 (pSmad1/5) and estrogen receptor (ER) were evaluated. Besides, the correlation between these IHC markers was also analyzed. RT-PCR and western blot were used to test relevant genes.
resultsCompared with other groups, the IUA-L group showed a significant decrease in the number of glands and MVD. And it also showed a significant increase in the stromal fibrosis rate and a-SMA level. Moreover, in the IUA-L group, TGF-β1 and pSmad3 levels were consistently high, and levels of BMP7, pSmad1/5 and ER were low. EMT markers E-cadherin was decreased, while N-cadherin was increased. Sham and control groups showed no significant difference in these markers. In addition, E-cadherin with a-SMA, fibrosis rate with BMP7, TGF-β1 with pSmad3 and BMP7 with pSmad1/5 showed correlation in IUA-L group, which had statistical significance. The mRNA expression of TGF-β1, a-SMA and ccn2 in 7 d IUA-L was higher than 7 d IUA-R while BMP7 was lower, which had significant difference. The protein expression of BMP7 in 7 d IUA-L was lower than 7 d IUA-R, which had significant difference.
conclusionsThese results suggest a potential role of Smad signaling together with EMT in endometrial fibrosis development.
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Identifiers
31497194PMC6731410W2990812435What OpenQuestion holds
Registered trials
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