ArticleAmerican journal of translational research2019
CircRNAs in exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 35 citations in OpenAlex.
- Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis.Clinical and translational medicine · 2026Review
- The role of extracellular vesicles in kidney disease progression.Kidney research and clinical practice · 2026Article
- Urinary microvesicles: a window into the kidney.Clinical kidney journal · 2025Review
- Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress.Chinese medicine · 2025Review
- Development of Mathematical Models Using circRNA Combinations (International journal of molecular sciences · 2025Article
- Understanding the Roles of Non-coding RNAs and Exosomal Non-Coding RNAs in Diabetic Nephropathy.Current molecular medicine · 2025Review
- Specificity of endothelial cells in endothelial dysfunction of diabetic kidney disease and their crosstalk with neighboring cells: an updated review.Frontiers in endocrinology · 2025Review
- Emerging roles of exosomes in the diagnosis and treatment of kidney diseases.Frontiers in pharmacology · 2025Review
- Research progress on small extracellular vesicles in diabetic nephropathy.Frontiers in cell and developmental biology · 2025Review
- Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease.Renal failure · 2024Review
- Endothelial cells derived extracellular vesicles promote diabetic arterial calcification via circ_0008362/miR-1251-5p/Runx2 axial.Cardiovascular diabetology · 2024Article
- Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications.Journal of translational medicine · 2024Review
- The mineralocorticoid receptor in diabetic kidney disease.American journal of physiology. Renal physiology · 2024Review
- Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review).International journal of molecular medicine · 2024Article
- Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review.Cell communication and signaling : CCS · 2024Review
- Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease.Frontiers in medicine · 2024Review
- Extracellular vesicles: mechanisms and prospects in type 2 diabetes and its complications.Frontiers in endocrinology · 2024Review
- Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression.American journal of physiology. Cell physiology · 2023Review
- Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases.Journal of nanobiotechnology · 2023Review
- Exosomes in Diabetic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the relationships between glomerular endothelial cells (GECs) and glomerular mesangial cells (GMCs) is important to identify the molecular mechanisms underlying diabetic nephropathy (DN). Exosomes carried with mRNA, microRNA, and protein play important roles in cell-to-cell communication. In this study, we showed that high glucose (HG)-treated GECs secreted a higher number of exosomes enriched in circRNAs compared with normal glucose (NG)-treated GECs. Differentially expressed circRNAs (DECs) were obtained by high-throughput sequencing. Of these DECs, the expressions of 217 DECs and 484 DECs in HG-treated GEC exosomes were significantly downregulated and upregulated, respectively, compared with NG-treated GEC exosomes. The functions of the DEC target genes were involved in the PI3K/AKT and MAPK pathways. Five DECs were randomly selected for identification by quantitative real-time PCR (qRT-PCR). Two DECs (circRNF169 and circSTRN3) were further selected for functional validation. Moreover, we demonstrated that exosomes released by HG-treated GECs promoted α-smooth muscle actin (α-SMA) expression. It also inhibited proliferation and promoted epithelial-mesenchymal transition (EMT) in GMCs. In addition, cell functional studies indicated that the knockdown and over-expression of two DECs (circRNF169 and circSTRN3) effectively inhibited or promoted cell proliferation and promoted or inhibited EMT, respectively. Thus, the results of this study provide new insights into the pathogenesis of DN that involves the intercellular transfer of circRNAs from GECs to GMCs via exosomes.
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31497190PMC6731409W2991193727What OpenQuestion holds
Registered trials
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