ArticleInternational journal of endocrinology and metabolism2019
Serum Uric Acid Status and Its Association with Bone Mineral Density in the Elderly People Aged 60 Years and More.
Article in International journal of endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Analyses of the relationship between hyperuricemia and osteoporosis.Scientific reports · 2021Trial
- An intelligent auxiliary diagnostic system for early osteoporosis screening using stacking ensemble learning.BMC medical informatics and decision making · 2026Article
- Association between serum uric acid levels and osteoporosis risk: evidence from a cross-sectional study and Mendelian randomization analysis.Clinical rheumatology · 2026Article
- Explainable machine learning for osteoporosis detection in patients with osteopenia: model development and validation using routine clinical data from an Asian cohort.Frontiers in endocrinology · 2026Article
- Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Serum uric acid/creatinine ratio and osteoporosis in the elderly: a NHANES study.Frontiers in medicine · 2025Article
- BMI mediates the association of serum uric acid with bone health: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES).BMC musculoskeletal disorders · 2024Article
- Cross-sectional analysis of the correlation between serum uric acid and trabecular bone score: NHANES 2005-2008.Scientific reports · 2023Article
- Comparison between linear regression and four different machine learning methods in selecting risk factors for osteoporosis in a Chinese female aged cohort.Journal of the Chinese Medical Association : JCMA · 2023Article
- Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study.Frontiers in endocrinology · 2023Article
- No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study.Scientific reports · 2021Article
- Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris.Frontiers in endocrinology · 2021Article
- Association of Serum Uric Acid Status With Bone Mineral Density in Adolescents Aged 12-19 Years.Frontiers in medicine · 2020Article
- The Association between Serum Uric Acid and Bone Mineral Density in Older Adults.International journal of endocrinology · 2020Article
- Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study.Journal of diabetes research · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is associated with decreased antioxidant defenses and serum uric acid (UA) as an antioxidant may exert a protective effect on bone mass.
objectivesThis study aimed to determine the association between serum UA and bone mineral density (BMD) in the elderly population.
methodsAll participants of the Amirkola Health and Ageing Project aged ≥ 60 years entered the study. BMD in the femoral neck (FN-BMD) and lumbar spine (LS-BMD) was determined by dual energy X-ray absorptiometry and osteoporosis was defined as BMD T-score < - 2.5 at either FN or LS. The patients were classified according to serum UA levels as < 4; 4 - 4.99; 5 - 5.99; 6 - 6.99 and > 7 mg/dL. In statistical analysis, the value of BMD as well as frequency of osteoporosis in each subgroup were compared with the control group (UA < 4 mg/dL).
resultsA total of 1080 patients were studied. By increasing serum UA from < 4 mg/dL to > 7 mg/dL the BMD at both measurement sites increased as well. The serum UA was associated with decreased risk of osteoporosis. In multivariate analysis, the odds of osteoporosis in the subgroup with serum UA levels between 4 - 4.99 mg/dL was significantly lower than the control group (OR = 0.66, 95% CI, 0.44 - 0.99). Age and female sex were associated with increased odds of osteoporosis (OR = 1.08, 95% CI, 1.05 - 1.10 and OR = 10.62, 95% CI, 7.53 - 14.97 respectively).
conclusionsThese findings indicate a negative association between serum UA and osteoporosis in the elderly population aged ≥ 60 years.
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