Evidence map›Paper›PMID 31497018›Full record

ArticleFrontiers in immunology2019

HIV Infection Is Associated With Downregulation of BTLA Expression on

Morgan S Barham, Deborah A Abrahams, Jeremiah Khayumbi, Joshua Ongalo, Joan Tonui, Angela Campbell, Marwou de Kock, Samuel Gurrion Ouma, Felix Hayara Odhiambo, Willem A Hanekom and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Pathogens (Basel, Switzerland) · 2025
    Article
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. CD4 T Cells inFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Morgan S BarhamEmory Vaccine Center, Emory University, Atlanta, GA, United States.
Deborah A AbrahamsSouth African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Jeremiah KhayumbiCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Joshua OngaloCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Joan TonuiCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Angela CampbellDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Marwou de KockSouth African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Samuel Gurrion OumaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Felix Hayara OdhiamboCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Willem A HanekomSouth African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Neel R GandhiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Cheryl L DayEmory Vaccine Center, Emory University, Atlanta, GA, United States.
Kenya Medical Research Institute · KEEmory University · USUniversity of Cape Town · ZASouth African Tuberculosis Vaccine Initiative · ZA

Funding

Role of antigen-specific T cell responses in the control of TBU19AI111211 · NIAID · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 2014 to 2020
$20.1M
NK cell-mediated regulation of T cell immunity in TB/HIV co-infectionR01AI111948 · NIAID · EMORY UNIVERSITY · PI DAY, CHERYL LIANE · 2014 to 2018
$3.7M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
Mechanisms of Immune Regulation in Mycobacterium Tuberculosis InfectionR01AI083156 · NIAID · UNIVERSITY OF CAPE TOWN · PI DAY, CHERYL LIANE · 2009 to 2012
$415k
NIAID NIH HHS K24 AI114444NIAID NIH HHS R01 AI083156NIAID NIH HHS R01 AI111948NIAID NIH HHS U19 AI111211
6 · The paper itself

Abstract

Nearly a quarter of the global population is infected with

Indexed as

AdultCD4-Positive T-LymphocytesDown-RegulationFemaleHIV InfectionsHumansMaleMycobacterium tuberculosisReceptors, ImmunologicTuberculosisYoung AdultBTLA protein, humanReceptors, Immunologicactive TB diseaseBTLACD4 T cellCTLA-4HIVLTBIMycobacterium tuberculosisPD-1

Identifiers

PMID31497018
PMCPMC6712065
OpenAlexW2965667409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.