Evidence map›Paper›PMID 31497012›Full record

ArticleFrontiers in immunology2019

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias.

Donjete Simnica, Simon Schliffke, Christoph Schultheiß, Nicola Bonzanni, Lorenzo F Fanchi, Nuray Akyüz, Barbara Gösch, Christian Casar, Benjamin Thiele, Janina Schlüter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Donjete SimnicaDepartment of Internal Medicine IV, Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Simon SchliffkeDepartment of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Christoph SchultheißDepartment of Internal Medicine IV, Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Nicola BonzanniENPICOM B.V., 's-Hertogenbosch, Netherlands.
Lorenzo F FanchiENPICOM B.V., 's-Hertogenbosch, Netherlands.
Nuray AkyüzDepartment of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Barbara GöschDepartment of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Christian CasarDepartment of Gastroenterology With Sections Infectious and Tropical Diseases, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Benjamin ThieleDepartment of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Janina SchlüterDepartment of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Ansgar W LohseDepartment of Gastroenterology With Sections Infectious and Tropical Diseases, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Mascha BinderDepartment of Internal Medicine IV, Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Martin Luther University Halle-Wittenberg · DEUniversität Hamburg · DEENPICOM (Netherlands) · NLUniversity Cancer Center Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune system. Using next-generation immunosequencing we profiled 59 T and B cell repertoires (

Indexed as

AdultAgedAged, 80 and overAutoimmune DiseasesB-LymphocytesHematologic DiseasesHigh-Throughput Nucleotide SequencingHumansImmunogenetic PhenomenaImmunoglobulin Heavy ChainsMiddle AgedReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesYoung AdultImmunoglobulin Heavy ChainsReceptors, Antigen, T-Cell, alpha-betaAICautoimmunitybiomarkerCLLGLIPHimmunosequencingNGS

Identifiers

PMID31497012
PMCPMC6713037
OpenAlexW2966282780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.