ArticleJournal of medical biochemistry2019
Thiol/Disulphide Homeostasis, Ischemia Modified Albumin, and Ferroxidase as Oxidative Stress Markers in Women with Obesity with Insulin Resistance.
Article in Journal of medical biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- The Predictive Role of Thiol/Disulfide Homeostasis as an Oxidative Stress Parameter in Sarcopenic Obesity.Medicina (Kaunas, Lithuania) · 2025Article
- Effects of use of metformin or combination of metformin and pioglitazone on oxidative stress in type 2 diabetes mellitus.Journal of medical biochemistry · 2025Article
- Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity.Nutrients · 2022Article
- A Prediction Model of the Incidence of Type 2 Diabetes in Individuals with Abdominal Obesity: Insights from the General Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population.Journal of medical biochemistry · 2021Article
- The role of oxidative stress in the development of obesity and obesity-related metabolic disorders.Journal of medical biochemistry · 2021Article
- Evaluation of the Association between Obesity Markers and Type 2 Diabetes: A Cohort Study Based on a Physical Examination Population.Journal of diabetes research · 2021Article
- Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population.Oxidative medicine and cellular longevity · 2021Article
- The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk.Journal of medical biochemistry · 2020Article
- Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemia-modified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and non-insulin-resistant groups in comparison with an overweight group.
methodsWe compared plasma thiol/disulphide, IMA levels, and ferroxidase activity between the study groups. We analyzed plasma thiol/disulphide homeostasis with a newly developed automated measurement method; IMA with Albumin Cobalt Binding Test and ferroxidase (ceruloplasmin) levels with an automated, colourimetric method.
resultsThere were no significant differences between insulin-resistant and non-insulin-resistant women with obesity in terms of plasma native thiol, total thiol, disulphide, disulphide/native thiol ratio, disulphide/total thiol or native thiol/total thiol values. Ferroxidase activity was higher in insulin-resistant than in non-insulin-resistant women with obesity and higher in the total women with obesity group than in the overweight subjects (p<0.001, and p=0.014, respectively). IMA was lower in the insulin-resistant group than in the non-insulin-resistant group and overweight groups (p=0.011, and p=0.042, respectively).
conclusionsThe significantly greater increase in ferroxidase activity in insulin-resistant subjects with obesity may reflect its role as a positive acute phase protein. These findings may be related to the pathogenesis of the disease. Changes in oxidative status occur in women with obesity, and partially in overweight subjects. The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron.
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