ArticleNature and science of sleep2019
The effects of aging on sleep parameters in a healthy, melatonin-competent mouse model.
Article in Nature and science of sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Dexmedetomidine Plus Stellate Ganglion Block Improves Postoperative Sleep Quality in Elderly Hip Arthroplasty Patients: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.BMC anesthesiology · 2025Trial
- Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Hippocampal Transcriptome Analysis in a Mouse Model of Chronic Unpredictable Stress Insomnia.Biomedicines · 2025Article
- A machine learning approach to predict postoperative sleep disturbance after total knee arthroplasty: a comparative study of multiple algorithms.Frontiers in medicine · 2025Article
- Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer.Nutrients · 2024Review
- Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health.Indian journal of clinical biochemistry : IJCB · 2024Review
- Intraoperative Sleep Spindle Activity and Postoperative Sleep Disturbance in Elderly Patients Undergoing Orthopedic Surgery: A Prospective Cohort Study.Nature and science of sleep · 2024Article
- Solriamfetol enhances wakefulness and improves cognition and anxiety in a murine model of OSA.Sleep medicine · 2023Article
- Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice.Biomedicines · 2023Article
- Article
- A Combination of Rosa Multiflora and Zizyphus Jujuba Enhance Sleep Quality in Anesthesia-Induced Mice.International journal of molecular sciences · 2022Article
- Article
- The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Validation of PiezoSleep Scoring Against EEG/EMG Sleep Scoring in Rats.Nature and science of sleep · 2022Article
- Changes in sleep EEG with aging in humans and rodents.Pflugers Archiv : European journal of physiology · 2021Review
- Brain activity and transcriptional profiling in mice under chronic jet lag.Scientific data · 2020Article
- Sleep and ageing: from human studies to rodent models.Current opinion in physiology · 2020Article
- Sleep Disturbances After General Anesthesia: Current Perspectives.Frontiers in neurology · 2020Review
- The Relationship between the Number of Daily Health-Related Behavioral Risk Factors and Sleep Health of the Elderly in China.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disturbances are common maladies associated with human age. Sleep duration is decreased, sleep fragmentation is increased, and the timing of sleep onset and sleep offset is earlier. These disturbances have been associated with several neurodegenerative diseases. Mouse models for human sleep disturbances can be powerful due to the accessibility to neuroscientific and genetic approaches, but these are hampered by the fact that most mouse models employed in sleep research have spontaneous mutations in the biosynthetic pathway(s) regulating the rhythmic production of the pineal hormone melatonin, which has been implicated in human sleep. PURPOSE AND
methodThe present study employed a non-invasive piezoelectric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melatonin biosynthesis, to investigate naturally-occurring changes in sleep and circadian parameters as the result of aging.
resultsThe results indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, while the timing of activity onset and acrophase is delayed in aged mice compared to younger mice.
conclusionThese data point to an effect of aging on the quality and timing of sleep in these mice but also that there are fundamental differences between control of sleep in humans and in laboratory mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.