ArticleCancer management and research2019
The role of circular RNA hsa_circ_0085616 in proliferation and migration of hepatocellular carcinoma cells.
Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Differentially expressed non-coding RNAs and their regulatory networks in liver cancer.Heliyon · 2023Review
- Review of novel functions and implications of circular RNAs in hepatocellular carcinoma.Frontiers in oncology · 2023Review
- The function and regulation network mechanism of circRNA in liver diseases.Cancer cell international · 2022Review
- Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway.Oncology letters · 2021Review
- Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles.Frontiers in oncology · 2021Review
- Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role.Critical reviews in oncology/hematology · 2020Review
- Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.Frontiers in bioengineering and biotechnology · 2020Article
- Circ_0000517 Contributes to Hepatocellular Carcinoma Progression by Upregulating TXNDC5 via Sponging miR-1296-5p.Cancer management and research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCircRNAs involved in the development of many diseases have been recently identified. However, the possible role of circRNAs in human hepatocellular carcinoma (HCC) remains to be investigated.
objectiveThis study aimed to identify the expression of hsa_circ_0085616 in different HCC cell lines and its function in HCC tumorigenesis.
methodsThe expression of hsa_circ_0085616 was first measured in 68 pairs of HCC tissues and matched normal adjacent tissues. Further analysis was performed in different HCC cell lines and human normal hepatic cell lines. Moreover, we down- or upregulated its expression by cell transfection in vitro. Cell proliferation, migration, invasion and apoptosis were measured, and proliferation-related signaling pathway proteins were also analyzed.
resultsWe found that hsa_circ_0085616 was highly expressed in all HCC cell lines compared to the normal liver cell line. Upregulation or downregulation of hsa_circ_0085616 expression could strengthen or weaken the proliferative ability of HCC cells in vitro. Moreover, the protein levels of β-catenin, p-ERK, and p-AKT, which play important roles in the typical proliferation pathway, were also affected by the expression of hsa_circ_0085616.
conclusionOur study indicated that hsa_circ_0085616 might be a potential biomarker and a new therapeutic target for HCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.