Evidence map›Paper›PMID 31496785›Full record

ArticleInternational journal of general medicine2019

The expression of microRNA 146a in patients with ischemic stroke: an observational study.

Hend G Kotb, Amal H Ibrahim, Eman F Mohamed, Omaima M Ali, Nagwa Hassanein, Dina Badawy, Ehab Abdelatty Aly

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Review
  7. Review
  8. MiRNA-146a-A Key Player in Immunity and Diseases.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hend G KotbDepartment of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Amal H IbrahimDepartment of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Eman F MohamedDepartment of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Omaima M AliDepartment of Internal Medicine, Faculty of Medicine, Aswan University, Aswan, Egypt.
Nagwa HassaneinDepartment of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Dina BadawyDepartment of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Ehab Abdelatty AlyHealth Radiation Research Department, National Center of Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
Al-Azhar University · EGAswan University · EGEgyptian Atomic Energy Authority · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe conducted the present prospective study to assess the level of microRNA (miRNA) 146a in patients with ischemic stroke and its correlation with patients' characteristics.

methodsWe conducted an observational study that included adult patients (≥18 years old) who presented within 24 hrs after the onset of the symptoms of acute ischemic stroke. In addition, age- and sex-matched healthy volunteers were included as control group. The primary outcome in the present study was the difference in miRNA 146a expression between patients with ischemic stroke and control group participants. The expression of miRNA 146a was measured using quantitative real-time PCR. Quantitative real-time PCR amplification and analysis were performed using Rotor-Gene Q thermal cycler.

resultsThe present study included 44 patients with ischemic stroke and 22 matched controls. Regarding the primary outcome of the present study, the median expression of miRNA 146a in patients with ischemic stroke was -1.98 fold (IQR -27.1-3.9) compared to 1.75 fold (IQR -2.25-5.27) in control group (

conclusionIn conclusion, the expression of miRNA 146a is significantly downregulated in ischemic stroke patients. Further studies are needed to assess its diagnostic utility and therapeutic potentials.

Indexed as

cerebral infarctioncomaischemic strokemiRNA 146a

Identifiers

PMID31496785
PMCPMC6691961
OpenAlexW2969012069

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.