Evidence map›Paper›PMID 31496771›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2019

Impact of

Ahmed Saleh, Mamdouh M Anwar, Ahmed E Zayed, Manal El Sayed Ezz Eldeen, Gamal Afifi, Hassien M Alnashiri, Asmaa Ms Gomaa, Mahmoud Abd-Elkareem, Alaa Sayed Abou-Elhamd, Emad S Shaheen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Diabetes and diabesity in the view of proteomics, drug, and plant-derived remedies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
    Review
  4. Article
  5. Structured water: effects on animals.Journal of animal science · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Ahmed SalehDepartment of Physics, Faculty of Science, Jazan University, Jazan, KSA.
Mamdouh M AnwarDepartment of Pharmacology, Faculty of Pharmacy, Jazan University, Jazan, KSA.
Ahmed E ZayedDepartment of Biology, Faculty of Science, Jazan University, Jazan, KSA.
Manal El Sayed Ezz EldeenEndocrine Unit, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Gamal AfifiDepartment of Physics, Faculty of Science, Jazan University, Jazan, KSA.
Hassien M AlnashiriDepartment of Biology, Faculty of Science, Jazan University, Jazan, KSA.
Asmaa Ms GomaaMedical Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud Abd-ElkareemDepartment of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Egypt.
Alaa Sayed Abou-ElhamdDepartment of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Egypt.
Emad S ShaheenMedical Research Centre, Jazan University , Jazan, KSA.
Ghada A MohamedEndocrine Unit, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Helal F HettaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-8541-7304
Ahmed M KotbDepartment of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Egypt.
Assiut University · EGJazan University · SACairo University · EGEgypt-Japan University of Science and Technology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 2 diabetes (T2D) is a widely distributed disease that affects large population worldwide. This study aimed to verify the role of MATERIALS AND

methodsT2D was induced by feeding the rats on a high-fat diet (20% fat, 45% carbohydrate, 22% protein) for eight weeks followed by intra-peritoneal injection of a single low dose of streptozotocin (25mg/Kg). Forty rats were randomly assigned to four groups (n=10 rats) as follows: non treated control and three diabetic groups. One diabetic group served as a positive control (diabetic), while the other two groups were orally administered with water extract of GB leaves (0.11 g/kg/day) and MW (600 gauss) for four weeks, respectively.

resultsThe β-cell mass and insulin expression in these cells increased markedly after both treatments, particularly in GB treated group. In addition, the immune-expression of the two antioxidant enzymes; glutathione and superoxide dismutase 2 (SOD2) in the pancreatic tissue demonstrated a down-regulation in GB and MW treated groups as compared with the diabetic group.

conclusionA four-week treatment of GB and MW protected pancreatic β-cell cells and improved their insulin expression and antioxidant status in type 2 diabetic rats.

Indexed as

Ginkgo biloba extractglutathionemagnetized waterSOD2type 2 diabetesβ-cell

Identifiers

PMID31496771
PMCPMC6689767
OpenAlexW2966694182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.