ArticleInfection and drug resistance2019
Augmented renal clearance is associated with inadequate antibiotic pharmacokinetic/pharmacodynamic target in Asian ICU population: a prospective observational study.
Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Sepsis-Specific Risk Factors for Augmented Renal Clearance (ARC) and the Effect of Inflammation on Duration of ARC in Patients with Sepsis: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- The Definition, Prevalence, and Risk Factors of Augmented Renal Clearance in Adult Patients on Antimicrobial Therapy: A Scoping Review.Infectious diseases & clinical microbiology · 2025Article
- Navigating pharmacokinetic and pharmacodynamics challenges of β-lactam antibiotics in patients with low body weight: efficacy, toxicity, and dosage optimization.Therapeutic advances in drug safety · 2025Article
- Risk Factors Associated with Antibiotic Exposure Variability in Critically Ill Patients: A Systematic Review.Antibiotics (Basel, Switzerland) · 2024Review
- Significant perioperative parameters affecting postoperative complications within 30 days following craniotomy for primary malignant brain tumors.Perioperative medicine (London, England) · 2023Article
- LC-MS/MS-Based Serum Metabolomics and Transcriptome Analyses for the Mechanism of Augmented Renal Clearance.International journal of molecular sciences · 2023Article
- Safety and Tolerability of Antimicrobial Agents in the Older Patient.Drugs & aging · 2023Review
- External Validation of the Augmented Renal Clearance Predictor in Critically Ill COVID-19 Patients.Antibiotics (Basel, Switzerland) · 2023Article
- Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study.Annals of intensive care · 2022Article
- Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance.European journal of drug metabolism and pharmacokinetics · 2022Review
- Predictive performance of reported vancomycin population pharmacokinetic model in patients with different renal function status, especially those with augmented renal clearance.European journal of hospital pharmacy : science and practice · 2022Article
- Prevalence and Risk Factors of Augmented Renal Clearance: A Systematic Review and Meta-Analysis.Pharmaceutics · 2022Review
- Combination of Pharmacokinetic and Pathogen Susceptibility Information To Optimize Meropenem Treatment of Gram-Negative Infections in Critically Ill Patients.Antimicrobial agents and chemotherapy · 2022Article
- The Role of Non-Enzymatic Degradation of Meropenem-Insights from the Bottle to the Body.Antibiotics (Basel, Switzerland) · 2021Article
- Evaluation of the MeroRisk Calculator, A User-Friendly Tool to Predict the Risk of Meropenem Target Non-Attainment in Critically Ill Patients.Antibiotics (Basel, Switzerland) · 2021Article
- A Regression Model to Predict Augmented Renal Clearance in Critically Ill Obstetric Patients and Effects on Vancomycin Treatment.Frontiers in pharmacology · 2021Article
- The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome.Journal of intensive care · 2020Article
- Effect of augmented renal clearance on the therapeutic drug monitoring of vancomycin in patients after neurosurgery.The Journal of international medical research · 2020Article
- Augmented Renal Clearance and How to Augment Antibiotic Dosing.Antibiotics (Basel, Switzerland) · 2020Review
- Therapeutic Drug Monitoring of Meropenem and Piperacillin in Critical Illness-Experience and Recommendations from One Year in Routine Clinical Practice.Antibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAugmented renal clearance (ARC) is common in critically ill patients and could result in subtherapeutic antibiotic concentration. However, data in the Asian population are still lacking. The aim of this study was to explore the incidence and risk factors of ARC and its effect on β-lactam pharmacokinetics/pharmacodynamics (PK/PD) in Asian populations admitted to a medical ICU. In addition, we evaluated the appropriateness of using three estimated glomerular filtration (eGFR) formulas [Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)] as screening tools.
methodsWe measured 2-, 8-, and 24-hr creatinine clearance (CL
resultsOf 100 patients, 46 (46%) manifested ARC. Younger age (<50 years) and lower Sequential Organ Failure Assessment score increased the likelihood of ARC. ARC resulted in a low chance of achieving 50% fT >4MIC (33% vs 75%,
conclusionARC is associated with inadequate β-lactam PK/PD target in Asian ICU.
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