Evidence map›Paper›PMID 31496687›Full record

ArticleInternational journal of nanomedicine2019

Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice.

Yanjie Yang, Shuangyu Lv, Fengling Wang, Yang An, Na Fang, Weijuan Zhang, Wei Zhao, Xiangqian Guo, Shaoping Ji

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yanjie YangSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Shuangyu LvSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Fengling WangSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Yang AnSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Na FangSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Weijuan ZhangSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Wei ZhaoSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Xiangqian GuoSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Shaoping JiSchool of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMn-doped ZnS quantum dots (QDs) with special luminescent properties have been widely researched and applied in various fields. Thus, their release toxicity and security cannot be ignored.

methodsIn the present study, the toxicity and non-targeted metabolomics of Mn-doped ZnS QDs were investigated after single intravenous injection. Serum metabolites were evaluated based on gas chromatography-mass spectrometry together with multivariate statistical analyses [principal component analysis, partial least squares discriminant analysis, and orthogonal PLS-DA].

resultsThe modified metabolites (variable importance in the projection (VIP) >1 and

conclusionOur study provides a general observation regarding the toxicity and potential metabolic responses of mice exposed to Mn-doped ZnS QDs.

Indexed as

MetabolomicsAnimalsBody WeightMaleManganeseMetabolomeMice, Inbred BALB CMultivariate AnalysisOrgan SizeQuantum DotsSulfidesZinc CompoundsManganeseSulfidesZinc Compoundszinc sulfideGC-MSmetabolomicsmiceMn-doped ZnS QDstoxicity

Identifiers

PMID31496687
PMCPMC6689551
OpenAlexW2966862533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.