Evidence map›Paper›PMID 31496642›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2019

Brittle cornea syndrome: current perspectives.

Andrew Walkden, Emma Burkitt-Wright, Leon Au

Open access · goldAbstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Brittle Cornea Syndrome: Molecular Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Homozygous Val6Gly Variation inMolecular syndromology · 2023
    Article
  6. Article
  7. Brittle cornea syndrome: A tale of three brothers.Indian journal of ophthalmology · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Systemic diseases and the cornea.Experimental eye research · 2021
    Review
  14. Case report of aIndian journal of ophthalmology · 2020
    Article
  15. Article
  16. Brittle cornea syndrome: current perspectives [Letter].Clinical ophthalmology (Auckland, N.Z.) · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew WalkdenManchester Royal Eye Hospital, Manchester University Foundation Trust, Manchester, UK.
Emma Burkitt-WrightGenetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Leon AuManchester Royal Eye Hospital, Manchester University Foundation Trust, Manchester, UK.
Manchester Academic Health Science Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brittle cornea syndrome (BCS) is a rare autosomal recessive connective tissue disorder characterised by severe corneal thinning, with the major ocular risk being spontaneous ocular perforation due to progressive stromal thinning and ectasia. It is a complex condition with limited treatment options. The purpose of this review is to highlight the difficulties associated with the condition and examine the available published evidence with regards to management.

Indexed as

brittle Corneacorneal ectasiaspontaneous corneal perforation

Identifiers

PMID31496642
PMCPMC6698176
OpenAlexW2968991114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.