Evidence map›Paper›PMID 31496615›Full record

ReviewWorld journal of gastroenterology2019

Methionine adenosyltransferases in liver cancer.

Ben Murray, Lucia Barbier-Torres, Wei Fan, José M Mato, Shelly C Lu

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Crosstalk BetweenCancers · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases.Journal of experimental & clinical cancer research : CR · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Current and emerging strategies for the prevention of hepatocellular carcinoma.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ben MurrayDivision of Digestive and Liver diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Lucia Barbier-TorresDivision of Digestive and Liver diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
Wei FanDivision of Digestive and Liver diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
José M MatoCIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology, Park of Bizkaia, Derio 48160, Bizkaia, Spain.
Shelly C LuDivision of Digestive and Liver diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States, shelly.lu@cshs.org.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESCenter for Digestive and Liver Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions within the cell. Mammalian systems express two genes,

Indexed as

AnimalsAntineoplastic AgentsCarcinoma, HepatocellularCell DedifferentiationCell Transformation, NeoplasticDisease Models, AnimalDisease ProgressionDown-RegulationGene Expression Regulation, EnzymologicHepatocytesHumansIsoenzymesLiverLiver NeoplasmsMethionine AdenosyltransferaseMiceAntineoplastic AgentsIsoenzymesMethionine AdenosyltransferaseS-AdenosylmethionineBiomarkersCholangiocarcinomaHepatocellular carcinomaLiver cancerMethionine adenosyltransferasesS-adenosylmethionineTherapeutic targets

Identifiers

PMID31496615
PMCPMC6710175
OpenAlexW2969679631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.