Evidence map›Paper›PMID 31496560›Full record

ArticleJournal of current glaucoma practice

Modulating Ocular Scarring in Glaucoma Filtration Surgery Using the Epigenetic Adjunct Suberoylanilide Hydroxamic Acid.

Cooper D Rodgers, Zachary L Lukowski, Jeff Min, Gina M Martorana, Mary-Kate Wilson, Jamie L Schaefer, Monica A Levine, Craig A Meyers, C Richard Blake, Gregory S Schultz and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current glaucoma practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Cooper D RodgersDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA; Department of Ophthalmology, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Zachary L LukowskiDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA; Department of Ophthalmology, Medical College of Georgia-Augusta University, Augusta, Georgia, USA.
Jeff MinDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA; Massachusetts General Hospital, Boston, Massachusetts, USA.
Gina M MartoranaDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA; Department of Dermatology, University of Florida, Gainesville, Florida, USA.
Mary-Kate WilsonDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Jamie L SchaeferDepartment of Ophthalmology, West Virginia University, Morgantown, West Virginia, USA.
Monica A LevineDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Craig A MeyersDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
C Richard BlakeDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Gregory S SchultzDepartment of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA.
Mark B SherwoodDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
University of Florida · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study is to assess the effectiveness of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDI) with a broad spectrum epigenetic activity, in improving filtration bleb survival as an adjunct therapy to glaucoma filtration surgery (GFS) in the rabbit model. MATERIALS AND

methodsEighteen New Zealand White rabbits underwent GFS in the left eye and were randomized to receive either a subconjunctival (SC) injection of 0.1 mL SAHA (9.25 μg/mL) or balanced saline solution (BSS) at the end of surgery, or a 3-minute intraoperative topical application of 0.4 mg/mL mitomycin-C (MMC). Bleb survival and histology were compared.

resultsBlebs of rabbits receiving injections of SAHA survived an average (mean ± SD) of 23.2 ± 2.7 days. SAHA rabbits showed a nonsignificant improvement over rabbits that received an injection of BSS, which had a mean survival time of 19.7 ± 2.7 days (

conclusionAlthough it was well tolerated, a single intraoperative injection of SAHA did not significantly prolong bleb survival in the rabbit model. CLINICAL SIGNIFICANCE: Epigenetic adjuncts hold promise for improving GFS outcome; however, future studies must continue to examine different administration protocols and dosages to substantiate their efficacy. HOW TO CITE THIS ARTICLE: Rodgers CD, Lukowski ZL,

Indexed as

EpigeneticsGlaucomaGlaucoma filtration surgerySAHASuberoylanilide hydroxamic acidTrabeculectomyVorinostat

Identifiers

PMID31496560
PMCPMC6710929
OpenAlexW2972882407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.