Evidence map›Paper›PMID 31496147›Full record

ReviewThe world journal of men's health2020

Treatment of Functional Hypogonadism Besides Pharmacological Substitution.

Giovanni Corona, Giulia Rastrelli, Annamaria Morelli, Erica Sarchielli, Sarah Cipriani, Linda Vignozzi, Mario Maggi

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The world journal of men's health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06280807 (OBServation of Environment and ReproductiVe Endocrine Effects Study), which is not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06280807 recruitingnot on this mapstarted 2024, after this paper: background citation

OBServation of Environment and ReproductiVe Endocrine Effects Study (OBSERVE Study)

TypeobservationalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran2024 to 2039Enrolled300ConditionsHypogonadism, Hypergonadism, Precocious Puberty, Late Puberty
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Review
  8. Review
  9. Article
  10. Age-related testosterone decline: mechanisms and intervention strategies.Reproductive biology and endocrinology : RB&E · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. The role of testosterone in male sexual function.Reviews in endocrine & metabolic disorders · 2022
    Review
  16. [Testosterone treatment].Urologie (Heidelberg, Germany) · 2022
    Article
  17. Review
  18. Article
  19. The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Giovanni CoronaEndocrinology Unit, Medical Department, Azienda Usl, Maggiore-Bellaria Hospital, Bologna, Italy.ORCID https://orcid.org/0000-0002-9894-2885
Giulia RastrelliAndrology, Female Endocrinology and Gender Incongruence Unit and Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-6164-4278
Annamaria MorelliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0001-8027-9870
Erica SarchielliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-4273-7858
Sarah CiprianiAndrology, Female Endocrinology and Gender Incongruence Unit and Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-0933-6657
Linda VignozziAndrology, Female Endocrinology and Gender Incongruence Unit and Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-0907-0630
Mario MaggiEndocrinology Unit and Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy. m.maggi@dfc.unifi.it.ORCID https://orcid.org/0000-0003-3267-4221
University of Florence · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A dichotomic distinction between "organic" and "functional" hypogonadism is emerging. The former is an irreversible condition due to congenital or "acquired" "organic" damage of the brain centers or of the testis. Conversely, the latter is a potentially reversible form, characterized by borderline low testosterone (T) levels mainly secondary to age-related comorbidities and metabolic derangements, including metabolic syndrome (MetS). Life-style modifications, - here reviewed and, when possible, meta-analyzed -, have documented that weight-loss and physical exercise are able to improve obesity-associated functional hypogonadism and its related sexual symptoms. A rabbit experimental model, of MetS originally obtained in our lab, showed that endurance training (PhyEx) completely reverted MetS-induced hypogonadotropic hypogonadism by reducing hypothalamus inflammation and testis fibrosis eventually allowing for a better corpora cavernosa relaxation and response to sildenafil. Physicians should strongly adapt all the reasonable strategies to remove/mitigate the known conditions underlying functional hypogonadism, including MetS and obesity. Physical limitations, including reduced muscle mass and increased fat mass, along with low self-confidence, also due to the sexual problems, might limit a subject's propensity to increase physical activity and dieting. A short term T treatment trial, by improving muscle mass and sexual function, might help hypogonadal obese patients to overcome the overfed, inactive state and to become physically and psychologically ready for changing their lifestyle.

Indexed as

Male hypogonadismObesityPhysical exerciseTestosteroneWeight loss

Identifiers

PMID31496147
PMCPMC7308235
OpenAlexW2971649306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.