ArticlePediatric pulmonology2020
Airway disease on chest computed tomography of preschool children with cystic fibrosis is associated with school-age bronchiectasis.
Article in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the "iMAging managEment of cySTic fibROsis" (MAESTRO) consortium.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- The measurement properties of tests and tools used in cystic fibrosis studies: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Trial
- Progression of Structural Lung Disease in DifferentJournal of fungi (Basel, Switzerland) · 2025Article
- A New Simple to Use Chest CT Scoring System: Validation Study.Pediatric pulmonology · 2025Article
- Automatic analysis of bronchus-artery dimensions to diagnose and monitor airways disease in cystic fibrosis.Thorax · 2023Article
- The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6-11 with cystic fibrosis in a real-world setting.Respiratory research · 2023Observational
- Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis.Thorax · 2023Article
- MDCT-based longitudinal automated airway and air trapping analysis in school-age children with mild cystic fibrosis lung disease.Frontiers in pediatrics · 2023Article
- The effect of CFTR modulators on structural lung disease in cystic fibrosis.Frontiers in pharmacology · 2023Article
- Health-Related Quality of Life Assessment: An Inexpensive Tool for Cystic Fibrosis Care.Indian journal of pediatrics · 2022Article
- Quantification of Phenotypic Variability of Lung Disease in Children with Cystic Fibrosis.Genes · 2021Review
- Airway disease on chest computed tomography of preschool children with cystic fibrosis is associated with school-age bronchiectasis.Pediatric pulmonology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway wall thickening and mucus plugging are important characteristics of cystic fibrosis (CF) lung disease in the first 5 years of life.The aim of this study is to investigate the association of lung disease in preschool children (age, 2-6) with bronchiectasis and other clinical outcome measures in the school age (age >7). Deidentified computed tomography-scans were annotated using Perth-Rotterdam annotated grid morphometric analysis for CF. Preschool %disease (a composite score of %airway wall thickening, %mucus plugging, and %bronchiectasis) and %MUPAT (a composite score of %airway wall thickening and %mucus plugging) were used as predictors for %bronchiectasis and several other school-age clinical outcomes. For statistical analysis, we used regression analysis, linear mixed-effects models and two-way mixed models. Sixty-one patients were included. %Disease increased significantly with age (P < .01). Preschool %disease and %MUPAT were significantly associated with school-age %bronchiectasis (P < .01 and P < .01, respectively). No significant association was found between preschool %disease and %MUPAT and school-age forced expiratory volume 1 (FEV1%) predicted and quality of life (P > .05). Cross-sectional, %disease in school-age was associated with a low FEV1% predicted and low quality of life (P = .01 and P = .007, respectively). %Disease can be considered an early marker of diffuse airways disease and is a risk factor for school-age bronchiectasis.
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