Evidence map›Paper›PMID 31496135›Full record

ArticlePhysiological reports2019

An exploration of the methods to determine the protein-specific synthesis and breakdown rates in vivo in humans.

Lars Holm, Kasper Dideriksen, Rie H Nielsen, Simon Doessing, Rasmus L Bechshoeft, Grith Højfeldt, Marcus Moberg, Eva Blomstrand, Søren Reitelseder, Gerrit van Hall

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. In vivoCurrent opinion in biotechnology · 2021
    Review
  10. Divergent Anabolic Response to Exercise in Young and Older Adult Men-Dependency on Time Frame of Measurement.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Lars HolmInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.ORCID 0000-0002-4392-9616
Kasper DideriksenInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Rie H NielsenInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Simon DoessingInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Rasmus L BechshoeftInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Grith HøjfeldtInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Marcus MobergAastrand Laboratory, Swedish School of Sport and Health Sciences, Stockholm, Sweden.ORCID 0000-0003-3747-0148
Eva BlomstrandAastrand Laboratory, Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Søren ReitelsederInstitute of Sports Medicine and Department of Orthopedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.
Gerrit van HallDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bispebjerg Hospital · DKUniversity of Copenhagen · DKKarolinska Institutet · SESwedish School of Sport and Health Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study explores the methods to determine human in vivo protein-specific myofibrillar and collagenous connective tissue protein fractional synthesis and breakdown rates. We found that in human myofibrillar proteins, the protein-bound tracer disappearance method to determine the protein fractional breakdown rate (FBR) (via

Indexed as

AdultAgedAlanineDeuteriumHumansMaleMiddle AgedMuscle ProteinsMuscle, SkeletalNitrogen IsotopesProtein Processing, Post-TranslationalTendonsAlanineDeuteriumMuscle ProteinsNitrogen IsotopesAmino acid recyclingdeuterated alaninedeuterated waterfractional breakdown ratefractional synthesis rateprotein turnoverstable isotope

Identifiers

PMID31496135
PMCPMC6732504
OpenAlexW2972449317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.