Evidence map›Paper›PMID 31496133›Full record

ArticlePhysiological reports2019

WNK4 limits distal calcium losses following acute furosemide treatment.

Mohammed Z Ferdaus, Brittany D K Gratreak, Lauren Miller, Jinge Si, James A McCormick, Chao-Ling Yang, David H Ellison, Andrew S Terker

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. WNK4 kinase: from structure to physiology.American journal of physiology. Renal physiology · 2021
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mohammed Z FerdausDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
Brittany D K GratreakDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
Lauren MillerDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
Jinge SiDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
James A McCormickDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
Chao-Ling YangDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
David H EllisonDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.
Andrew S TerkerDivision of Nephrology, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-1498-9043
Oregon Health & Science University · US

Funding

WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
VANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8M
Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
American Heart Association-American Stroke Association 17POST33670206NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK098141NIDDK NIH HHS T32 DK007569
6 · The paper itself

Abstract

The distal nephron is essential for calcium homeostasis. This is evidenced by disordered calcium transport following disrupted distal nephron function occurring in salt-wasting tubulopathies or with diuretic use. A plethora of studies support a role for WNK4 in thick ascending limb (TAL) and distal convoluted tubule ion transport with most studies focusing on sodium transport. Little is known about the in vivo role of WNK4 in regulating calcium homeostsis. Here, we investigated the role of WNK4 in regulating distal nephron calcium transport using WNK4 knockout animals (WNK4

Indexed as

AnimalsCalcium ChannelsCalcium, DietaryDiureticsFurosemideKidney Tubules, ProximalMaleMiceMice, Inbred C57BLProtein Serine-Threonine KinasesRenal EliminationRenal InsufficiencySodiumTRPV Cation ChannelsCalcium ChannelsCalcium, DietaryDiureticsFurosemidePrkwnk4 protein, mouseProtein Serine-Threonine KinasesSodiumTrpv5 protein, mouseTRPV Cation ChannelsCalciumdistal convoluted tubulethick ascending limbWNK4

Identifiers

PMID31496133
PMCPMC6732491
OpenAlexW2972545125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.