ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2019
Post-traumatic stress disorder: a state-of-the-art review of evidence and challenges.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 18 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
210 citing papers in PubMed, 18 syntheses or guidelines pooled it.
- Linguistic markers for identifying post-traumatic stress disorder and associated symptoms: a systematic literature review.Journal of the American Medical Informatics Association : JAMIA · 2025Pooled it
- Pooled it
- Post-Traumatic Stress Disorder (PTSD) Resulting from Road Traffic Accidents (RTA): A Systematic Literature Review.International journal of environmental research and public health · 2025Pooled it
- Psychotherapies for adults with complex presentations of PTSD: a clinical guideline and five systematic reviews with meta-analyses.BMJ mental health · 2025Pooled it
- Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses.The Australian and New Zealand journal of psychiatry · 2025Pooled it
- Mind-body intervention for post-traumatic stress disorder in adolescents: a systematic review and network meta-analysis.BMC psychiatry · 2025Pooled it
- Post-traumatic stress disorder in youth exposed to the Syrian conflict: A systematic review and meta-analysis of prevalence and determinants.Journal of health psychology · 2024Pooled it
- Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence.Ageing research reviews · 2024Pooled it
- Hair Cortisol Research in Posttraumatic Stress Disorder - 10 Years of Insights and Open Questions. A Systematic Review.Current neuropharmacology · 2024Pooled it
- Pooled it
- The role of post-trauma stress symptoms in the development of chronic musculoskeletal pain and disability: A systematic review.European journal of pain (London, England) · 2023Pooled it
- Eye Movement Desensitization and Reprocessing versus Cognitive Behavior Therapy for Treating Post-Traumatic Stress Disorder: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Trauma-focused guided self-help interventions for posttraumatic stress disorder: A meta-analysis of randomized controlled trials.Depression and anxiety · 2022Pooled it
- The effects of psychological interventions on neurocognitive functioning in posttraumatic stress disorder: a systematic review.European journal of psychotraumatology · 2022Pooled it
- The impact of childhood trauma on psychological interventions for depression during pregnancy and postpartum: a systematic review.Archives of women's mental health · 2021Pooled it
- Prevalence and Determinants of Immediate and Long-Term PTSD Consequences of Coronavirus-Related (CoV-1 and CoV-2) Pandemics among Healthcare Professionals: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Assessing anxiety, depression and insomnia symptoms among Ebola survivors in Africa: A meta-analysis.PloS one · 2021Pooled it
- Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts.Frontiers in public health · 2021Pooled it
- Impact of posttraumatic stress disorder and comorbid psychiatric conditions on suicide reattempts.European journal of psychotraumatology · 2025Trial
- Rethinking Regret: Reappraisal Tendencies Buffer Regret for ICU Surrogates Following Patient Death.Western journal of nursing research · 2025Trial
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic stress disorder (PTSD) is arguably the most common psychiatric disorder to arise after exposure to a traumatic event. Since its formal introduction in the DSM-III in 1980, knowledge has grown significantly regarding its causes, maintaining mechanisms and treatments. Despite this increased understanding, however, the actual definition of the disorder remains controversial. The DSM-5 and ICD-11 define the disorder differently, reflecting disagreements in the field about whether the construct of PTSD should encompass a broad array of psychological manifestations that arise after trauma or should be focused more specifically on trauma memory phenomena. This controversy over clarifying the phenotype of PTSD has limited the capacity to identify biomarkers and specific mechanisms of traumatic stress. This review provides an up-to-date outline of the current definitions of PTSD, its known prevalence and risk factors, the main models to explain the disorder, and evidence-supported treatments. A major conclusion is that, although trauma-focused cognitive behavior therapy is the best-validated treatment for PTSD, it has stagnated over recent decades, and only two-thirds of PTSD patients respond adequately to this intervention. Moreover, most people with PTSD do not access evidence-based treatment, and this situation is much worse in low- and middle-income countries. Identifying processes that can overcome these major barriers to better management of people with PTSD remains an outstanding challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.