ArticleThe EMBO journal1988
Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases.Molecular neurobiology · 2025Review
- Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.Molecular systems biology · 2022Article
- Immediate Early Gene c-fos in the Brain: Focus on Glial Cells.Brain sciences · 2022Review
- Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.The Journal of biological chemistry · 2017Article
- A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.Biology open · 2017Article
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- The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers.Molecular and cellular biology · 1998Article
- AP-1 factors play an important role in transformation induced by the v-rel oncogene.Molecular and cellular biology · 1998Article
- DNA binding and transactivation properties of Fos variants with homodimerization capacity.Nucleic acids research · 1997Article
- The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.The EMBO journal · 1996Article
- Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma.The Journal of cell biology · 1996Article
- Journey to the surface of the cell: Fos regulation and the SRE.The EMBO journal · 1995Review
- Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.Molecular and cellular biology · 1995Article
- Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.Molecular and cellular biology · 1995Article
- Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.Molecular and cellular biology · 1994Article
- Negative regulation of transcription in eukaryotes.The Biochemical journal · 1993Review
- Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.The EMBO journal · 1993Article
- Antisense rescue defines specialized and generalized functional domains for c-Fos protein.Molecular and cellular biology · 1993Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient accumulation of c-fos RNA following serum stimulation requires both a conserved 5' regulatory element and sequences at the 3' end of the gene. Here we show that mutations at the C terminus of Fos protein, of the type found in a virally-transduced actively transforming Fos variant, prevent the rapid down-regulation of c-fos transcription that occurs following serum-induced activation. Fos mutants that prevent down-regulation are dominant, acting in trans to prevent down-regulation of a co-transfected c-fos gene. Co-transfection experiments suggest that this effect is mediated by multiple sequence elements in the 5'-flanking region. Analysis of different Fos mutants showed that replacement of Fos sequences C-terminal to amino acid 337 with heterologous polypeptide, rather than simple truncation of the protein, is required to produce mutants defective in down-regulation. The results are discussed with reference to transformation by Fos.
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