ArticleNeuron2019
Functional Logic of Layer 2/3 Inhibitory Connectivity in the Ferret Visual Cortex.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Article
- Article
- Prediction of future input explains lateral connectivity in primary visual cortex.Current biology : CB · 2025Article
- Article
- Comprehensive software suite for functional analysis and synaptic input mapping of dendritic spines imagedNeurophotonics · 2024Article
- Impact of Acute Visual Experience on Development of LGN Receptive Fields in the Ferret.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A model for the development of binocular congruence in primary visual cortex.Scientific reports · 2022Article
- Development of visual response selectivity in cortical GABAergic interneurons.Nature communications · 2022Article
- Mechanism underpinning the sharpening of orientation and spatial frequency selectivities in the tree shrew (Tupaia belangeri) primary visual cortex.Brain structure & function · 2022Article
- A Model for the Origin of Motion Direction Selectivity in Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cortical synaptic architecture supports flexible sensory computations.Current opinion in neurobiology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Understanding how cortical inhibition shapes circuit function requires identifying the connectivity rules relating the response properties of inhibitory interneurons and their postsynaptic targets. Here we explore the orientation tuning of layer 2/3 inhibitory inputs in the ferret visual cortex using a combination of in vivo axon imaging, functional input mapping, and physiology. Inhibitory boutons exhibit robust orientation-tuned responses with preferences that can differ significantly from the cortical column in which they reside. Inhibitory input fields measured with patterned optogenetic stimulation and intracellular recordings revealed that these inputs originate from a wide range of orientation domains, inconsistent with a model of co-tuned inhibition and excitation. Intracellular synaptic conductance measurements confirm that individual neurons can depart from a co-tuned regime. Our results argue against a simple rule for the arrangement of inhibitory inputs supplied by layer 2/3 circuits and suggest that heterogeneity in presynaptic inhibitory networks contributes to neural response properties.
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Registered trials
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