ArticleNeuron2019
Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Efficient and reproducible pipelines for spike sorting large-scale electrophysiology data.eLife · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Bridging the Gap: Integrated High-Density Microelectrode Arrays for Cellular, Organoid, and Clinical Electrophysiology.Micromachines · 2026Review
- Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings.Microsystems & nanoengineering · 2026Article
- A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex.Frontiers in neuroscience · 2026Article
- Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys.Npj complexity · 2026Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes.Neurophotonics · 2024Article
- Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior.Cell reports · 2024Article
- Inference of network connectivity from temporally binned spike trains.Journal of neuroscience methods · 2024Article
- Through-polymer, via technology-enabled, flexible, lightweight, and integrated devices for implantable neural probes.Microsystems & nanoengineering · 2024Article
- Blazed oblique plane microscopy reveals scale-invariant inference of brain-wide population activity.Nature communications · 2023Article
- Construction and use of an adaptive optics two-photon microscope with direct wavefront sensing.Nature protocols · 2023Review
- Article
- Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity.Annual review of biomedical engineering · 2023Review
- Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Translational opportunities and challenges of invasive electrodes for neural interfaces.Nature biomedical engineering · 2023Review
- Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents.Nature biomedical engineering · 2023Article
- Post-explant profiling of subcellular-scale carbon fiber intracortical electrodes and surrounding neurons enables modeling of recorded electrophysiology.Journal of neural engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The classic approach to measure the spiking response of neurons involves the use of metal electrodes to record extracellular potentials. Starting over 60 years ago with a single recording site, this technology now extends to ever larger numbers and densities of sites. We argue, based on the mechanical and electrical properties of existing materials, estimates of signal-to-noise ratios, assumptions regarding extracellular space in the brain, and estimates of heat generation by the electronic interface, that it should be possible to fabricate rigid electrodes to concurrently record from essentially every neuron in the cortical mantle. This will involve fabrication with existing yet nontraditional materials and procedures. We further emphasize the need to advance materials for improved flexible electrodes as an essential advance to record from neurons in brainstem and spinal cord in moving animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.