ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
Cognitive function after surgery with regional or general anesthesia: A population-based study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Early Cognitive Function after Deep Sedation Using Different Anesthetic Agents in Pediatric Patients: A Prospective, Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Outpatient flexible cystoscopy in urogynaecology: a tertiary hospital's experience.Irish journal of medical science · 2025Observational
- Healthcare Professionals' Perceptions of Pre-, Peri-, and Postoperative Virtual Reality Immersion in Elderly Patients.Healthcare (Basel, Switzerland) · 2025Article
- Preoperative biomarkers associated with delayed neurocognitive recovery.Journal of clinical monitoring and computing · 2025Observational
- The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review.Current Alzheimer research · 2024Review
- MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity.Pharmaceutics · 2023Review
- Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.Psychopharmacology · 2022Article
- Neuroinflammation in perioperative neurocognitive disorders: From bench to the bedside.CNS neuroscience & therapeutics · 2022Review
- Cerebral Hypoxia: Its Role in Age-Related Chronic and Acute Cognitive Dysfunction.Anesthesia and analgesia · 2021Review
- Association of Hospitalization with Long-Term Cognitive Trajectories in Older Adults.Journal of the American Geriatrics Society · 2021Observational
- Evaluating memory dysfunction after spinal anesthesia among patients undergoing elective surgery: Descriptive-analytical study.Annals of medicine and surgery (2012) · 2021Article
- Association between surgery with anesthesia and cognitive decline in older adults: Analysis using shared parameter models for informative dropout.Journal of clinical and translational science · 2020Article
- Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults.British journal of anaesthesia · 2020Article
- Exposure to surgery with regional anesthesia and cortical thickness in older adults.Alzheimer's & dementia (New York, N. Y.) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionOur aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA).
methodsLongitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA.
resultsWhen compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of -0.041, P = .011) and GA (-0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (-0.065, P < .001) but not RA (-0.011, P = .565).
conclusionsOlder adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.