Evidence map›Paper›PMID 31495533›Full record

ArticleStructure (London, England : 1993)2019

The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin.

Hyunbum Jang, Avik Banerjee, Kendra Marcus, Lee Makowski, Carla Mattos, Vadim Gaponenko, Ruth Nussinov

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. The mechanism of activation of MEK1 by B-Raf and KSR1.Cellular and molecular life sciences : CMLS · 2022
    Article
  10. Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Mechanistic Differences of Activation of Rac1The journal of physical chemistry. B · 2021
    Article
  16. Inhibition of Nonfunctional Ras.Cell chemical biology · 2021
    Review
  17. The mechanism of activation of monomeric B-Raf V600E.Computational and structural biotechnology journal · 2021
    Article
  18. Article
  19. Article
  20. Insight into the structures of Interleukin-18 systems.Computational biology and chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hyunbum JangComputational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Avik BanerjeeDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Kendra MarcusDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Lee MakowskiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Carla MattosDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Vadim GaponenkoDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Ruth NussinovComputational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: nussinor@mail.nih.gov.
Northeastern University · USUniversity of Illinois Chicago · USFrederick National Laboratory for Cancer Research · USTel Aviv University · IL

Funding

Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
Biomolecular Recognition and Binding MechanismsZIABC010441 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$9.4M
Regulation of tyrosine kinase signaling through interaction with membrane lipidsR01CA188427 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAPONENKO, VADIM V, TYNER, ANGELA L · 2015 to 2019
$2.1M
Protein Structure, Stability, and Amyloid FormationZ01BC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2002 to 2008
$1.4M
Intramural NIH HHS Z01 BC010440Intramural NIH HHS ZIA BC010441NCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA188427NIGMS NIH HHS P41 GM103485
6 · The paper itself

Abstract

Ca

Indexed as

AnimalsBinding SitesCalmodulinChickensMethylationMolecular Docking SimulationPrenylationProtein BindingProtein Processing, Post-TranslationalProto-Oncogene Proteins p21(ras)CalmodulinProto-Oncogene Proteins p21(ras)farnesylation and methylationhypervariable regionKRASMD simulationNMRphosphatidylinositolPI3KPIP(2)post-translational modificationsSAXS

Identifiers

PMID31495533
PMCPMC8194365
OpenAlexW2971835376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.