Evidence map›Paper›PMID 31495452›Full record

ArticleTrends in neurosciences2019

Microglia in Memory Decline from Zika Virus and West Nile Virus Infection.

Jennifer Tisoncik-Go, Michael Gale

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. SARS-CoV-2, Trait Anxiety, and the Microbiome.Frontiers in psychiatry · 2021
    Review
  2. Review
  3. Review
  4. Neurocognitive impacts of arbovirus infections.Journal of neuroinflammation · 2020
    Review
  5. CNS Macrophages and Infant Infections.Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jennifer Tisoncik-GoCenter for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA.
Michael GaleCenter for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA. Electronic address: mgale@uw.edu.

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Innate Immune Regulation of Zika Virus InfectionR01AI145296 · NIAID · UNIVERSITY OF WASHINGTON · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$4.1M
NIAID NIH HHS R01 AI145296NIH HHS P51 OD010425
6 · The paper itself

Abstract

Neurotropic viral infection can result in complications underscored by persistent T cell presence in the brain linked with cognitive decline. A recent study by Garber et al. showed that sustained T cell production of interferon (IFN)-γ mediating microglia activation triggers cognitive decline during recovery from Zika virus (ZIKV) or West Nile virus (WNV) infection.

Indexed as

Cognitive DysfunctionFlavivirusWest Nile FeverWest Nile virusZika VirusZika Virus InfectionHumansMemory DisordersMicrogliaT-Lymphocytesflavivirusmemorymicroglia

Identifiers

PMID31495452
PMCPMC8186266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.