ReviewThe journal of allergy and clinical immunology. In practice
Cephalosporin Allergy: Current Understanding and Future Challenges.
Review in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- "Point education" and "rotation communication" on antimicrobial policy implementation: an interrupted time series analysis of declining cephalosporin skin test rates.BMC health services research · 2026Observational
- Performance of PEN-FAST and CEPH-FAST for Cephalosporin Allergy Delabeling.Clinical and translational allergy · 2026Article
- Kounis Syndrome in Cardiac Surgery: Pathophysiology, Antimicrobial Triggers, and Perioperative Recognition and Management.Medical sciences (Basel, Switzerland) · 2026Review
- Characterizing β-lactam allergy prevalence among patients receiving infectious disease specialty care within a large US healthcare system in Washington.JAC-antimicrobial resistance · 2026Article
- Direct challenges are safe and effective in children with low-risk allergies to oral cephalosporins.The journal of allergy and clinical immunology. In practice · 2026Article
- Complex Hypertrophic Scar and Ventral Hernia Formation Following Laparoscopic Cholecystectomy: A Case Report.Cureus · 2026Article
- Ceftriaxone-Induced Pancytopenia: A Case Report.Hematology reports · 2025Article
- Engineering nanoallergens to investigate origins of immunogenicity and cross-reactivity in cephalosporin allergy.The Journal of allergy and clinical immunology · 2025Article
- Efficacy of Three Kayviruses AgainstAntibiotics (Basel, Switzerland) · 2025Article
- Evaluation of cephalosporin allergy: Survey of drug allergy experts.The journal of allergy and clinical immunology. Global · 2025Article
- Urticaria-Like Hypersensitivity Reaction Following Botulinum Toxin Injection: A Case Report of Possible Interaction with β-Lactam Antibiotics.International medical case reports journal · 2025Article
- [A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Cephalosporin Allergy: Updates on Diagnostic Testing.Current allergy and asthma reports · 2024Review
- Toxic epidermal necrolysis following heart transplantation may caused by cefoperazone sodium and sulbactam sodium.Journal of cardiothoracic surgery · 2024Article
- Glutathione dynamics in subcellular compartments and implications for drug development.Current opinion in chemical biology · 2024Review
- Clues of HLAs, metabolic SNPs, and epigenetic factors in T cell-mediated drug hypersensitivity reactions.Heliyon · 2024Review
- Association of HLA alleles with cephalosporin allergy in the Taiwanese population.Scientific reports · 2024Article
- The Assessment and Efficiency of Cefixime in Upper Respiratory Tract Infections: Insights and Perspectives.Cureus · 2024Review
- Successful rapid liposomal amphotericin B desensitization in pediatric case series.Allergy and asthma proceedings · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
Cephalosporins are commonly used antibiotics both in hospitalized patients and in outpatients. Hypersensitivity reactions to cephalosporins are becoming increasingly common with a wide range of immunopathologic mechanisms. Cephalosporins are one of the leading causes for perioperative anaphylaxis and severe cutaneous adverse reactions. Patients allergic to cephalosporins tend to tolerate cephalosporins with disparate R1 side chains but may react to other beta-lactams with common R1 side chains. Skin testing for cephalosporins has not been well validated but appears to have a good negative predictive value for cephalosporins with disparate R1 side chains. In vitro tests including basophil activation tests have lower sensitivity when compared with skin testing. Rapid drug desensitization procedures are safe and effective and have been used successfully for immediate and some nonimmediate cephalosporin reactions. Many gaps in knowledge still exist regarding cephalosporin hypersensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.