Evidence map›Paper›PMID 31495050›Full record

SynthesisCancer science2019

Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review.

Rabeia Almahmoudi, Merimaija Kasanen, Meri Sieviläinen, Abdelhakim Salem, Matti Pirinen, Tuula Salo, Ahmed Al-Samadi

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. The prognostic value of lymphatic vessel density in squamous cell carcinoma of the tongue: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Microvascular density and tumor budding in oral squamous cell carcinoma.Medicina oral, patologia oral y cirugia bucal · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rabeia AlmahmoudiDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Merimaija KasanenDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Meri SieviläinenDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Abdelhakim SalemDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Matti PirinenInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Tuula SaloDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.
Ahmed Al-SamadiDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-1938-2136
University of Helsinki · FIStatistics Finland · FI

Funding

Cancer Society of FinlandDoctoral Programme in Clinical ResearchEmil Aaltonen FoundationHelsinki University Central Hospital research fundsOulu University HospitalSigrid Juséliuksen SäätiöSuomen Hammaslääkäriseura Apollonia
6 · The paper itself

Abstract

Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis through blood and lymphatic vessels. We undertook a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We carried out a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, lymphatic vessel endothelial hyaluronan receptor-1, and D2-40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2-40

Indexed as

Antibodies, Monoclonal, Murine-DerivedAntigens, CD34Biomarkers, TumorCarcinoma, Squamous CellEndoglinFactor VIIIHumansHyaluronan ReceptorsLymphangiogenesisLymphatic VesselsMicrovesselsNeovascularization, PathologicPlatelet Endothelial Cell Adhesion Molecule-1PrognosisTongue NeoplasmsVesicular Transport ProteinsAntibodies, Monoclonal, Murine-DerivedAntigens, CD34Biomarkers, TumorEndoglinENG protein, humanF8 protein, humanFactor VIIIHyaluronan ReceptorsLYVE1 protein, humanmonoclonal antibody D2-40PECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Vesicular Transport Proteinsbiomarkerblood microvessel densitylymphatic vessel densityprognosistongue squamous cell carcinoma

Identifiers

PMID31495050
PMCPMC6824997
OpenAlexW2972022926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.