Evidence map›Paper›PMID 31494826›Full record

ArticleMolecular neurobiology2020

Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury.

Lei Liu, Mary K Vollmer, Marie G Kelly, Victoria M Fernandez, Tyler G Fernandez, Hocheol Kim, Sylvain Doré

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

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  11. A pure compound fromHeliyon · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lei LiuDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA.
Mary K VollmerDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA.
Marie G KellyDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA.
Victoria M FernandezDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA.
Tyler G FernandezDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA.
Hocheol KimDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, 130-701, South Korea.
Sylvain DoréDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, University of Florida, 1275 Center Drive, Biomed Sci J493, Gainesville, FL, 32610, USA. sdore@ufl.edu.ORCID http://orcid.org/0000-0003-3771-5109
University of Florida · USKyung Hee University · KR

Funding

Role of Prostaglandin Receptors in StrokeR01NS046400 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2003 to 2014
$3.0M
Better Understanding of the Neuroprotective Mechanisms of Korean Ginseng in StrokR01AT007429 · NCCIH · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2012 to 2016
$2.2M
NCCIH NIH HHS R01 AT007429NINDS NIH HHS R01 NS046400
6 · The paper itself

Abstract

Recently, dimethyl fumarate (DMF) and Korean red ginseng (ginseng), based on their purported antioxidative and anti-inflammatory properties, have exhibited protective potential in various neurological conditions. Their effects on cerebral ischemia and underlying mechanisms remain inconclusive; however, increasing evidence indicates the involvement of the transcriptional factor Nrf2. This study evaluated the preventive effects of DMF and ginseng on hippocampal neuronal damage following hypoxia-ischemia (HI) and assessed the contributions of reactive gliosis and the Nrf2 pathway. Adult wild type (WT) and Nrf2

Indexed as

AntioxidantsBrain IschemiaNeuroprotective AgentsNF-E2-Related Factor 2PanaxAnimalsAstrocytesDimethyl FumarateHippocampusMice, KnockoutMicrogliaNeuroprotectionAntioxidantsDimethyl FumarateNeuroprotective AgentsNF-E2-Related Factor 2AstrocyteAstrogliosisMicrogliaOxidative stressStrokeTranscriptional factor

Identifiers

PMID31494826
PMCPMC6980429
OpenAlexW2971368165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.