ArticleClinical and experimental nephrology2019
Low birth weight is associated with decline in renal function in Japanese male and female adolescents.
Article in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- A case of hypertensive emergency in a patient who had a history of very low birth weight.CEN case reports · 2026Article
- A novel mouse model for investigating the long-term impact of reduced nephron numbers on renal function and salt sensitivity.Pediatric research · 2025Article
- Kidney volume and function of low-birth-weight children at 5 years: impact of singleton and twin birth.Pediatric nephrology (Berlin, Germany) · 2025Article
- Should the Definition of Low Birth Weight Be Same in Every Ethnicity Considering the DOHaD Concept?Pediatric reports · 2025Article
- Reductions in estimated glomerular filtration rate during puberty in GH-treated children born small for gestational age are associated with prematurity and low birth weight, not the dosage of GH treatment.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Article
- A Case of Focal Segmental Glomerulosclerosis in a Young Girl with a Very Low Birth Weight.Pediatric reports · 2022Article
- Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
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Authors and funding
11 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLow birth weight (LBW) is a risk factor for chronic kidney disease (CKD) in later life and is becoming increasingly common in developed countries, including Japan. Furthermore, a serial decrease in birth weight has been associated with an increasing prevalence of CKD stage 2 in male Japanese adolescents. Sex-specific differences affect CKD susceptibility, and the association between birth weight and CKD in women, has not been elucidated. In this study, we investigated the sex-specific effect of LBW on renal function.
methodsAnnual cross-sectional data of 2417 Japanese adolescents (males 1736; females 681), aged 15-16 years, were evaluated over 8 years (2007-2014).
resultsOver the study period, mean birth weights decreased significantly in males (p < 0.01) and females (p < 0.05). Furthermore, both sexes showed significant decrease in estimated glomerular filtration rates corresponding to the birth weight reduction. The prevalence of CKD stage 2 also increased in males (from 26.0 to 32.4%, p < 0.01) and females (from 6.3 to 18.5%, p < 0.05). The incidence of CKD stage 2 was significantly related to history of LBW (males: odds ratio 1.73; 95% confidence interval 1.06-2.80; p < 0.05; females: odds ratio 3.29; 95% confidence interval 1.25-8.02; p < 0.05).
conclusionsOur data revealed that renal function and birth weight have decreased over time, in healthy Japanese adolescents. In view of the recent declining trend demonstrated by birth weight in Japan, we speculate that the prevalence of CKD might increase in the future.
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