ArticleJournal of bone and mineral metabolism2020
Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.
Article in Journal of bone and mineral metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Protective role of irisin on bone in osteoporosis: a systematic review of rodent studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Potential effect of Irisin on sarcopenia: a systematic review.BMC musculoskeletal disorders · 2025Pooled it
- Sex specific effects of irisin on the skeleton.Bone research · 2026Review
- Bone-muscle interactions.Osteoporosis and sarcopenia · 2025Review
- Calcium/Calmodulin-Dependent Protein Kinase II Inhibitors Mitigate High-Fat Diet-Induced Obesity in Mice.Journal of obesity · 2025Article
- The role of bone-derived factors in bone and muscle communication.Frontiers in endocrinology · 2025Review
- Crosstalk between muscle and bone.Journal of bone and mineral metabolism · 2024Review
- Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma.JBMR plus · 2024Article
- Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia.Biomedicines · 2024Review
- Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity.International journal of molecular sciences · 2023Article
- Impact of simple equation for estimating appendicular skeletal muscle mass in patients with stable coronary artery disease undergoing percutaneous coronary intervention.International journal of cardiology. Heart & vasculature · 2023Article
- Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta.Journal of orthopaedic translation · 2023Article
- Role of irisin in bone diseases.Frontiers in endocrinology · 2023Review
- The roles of sclerostin and irisin on bone and muscle of orchiectomized rats.BMC musculoskeletal disorders · 2022Article
- Irisin and Bone in Sickness and in Health: A Narrative Review of the Literature.Journal of clinical medicine · 2022Review
- Irisin improves delayed bone repair in diabetic female mice.Journal of bone and mineral metabolism · 2022Article
- Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke.Neuromolecular medicine · 2022Review
- Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence.International journal of molecular sciences · 2021Review
- Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice.Journal of bone and mineral metabolism · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Androgen deficiency plays a crucial role in the pathogenesis of male osteoporosis and sarcopenia. Myokines have recently been identified as humoral factors that are involved in the interactions between muscle and bone; however, the influence of androgen deficiency on these interactions remains unclear. Therefore, we herein investigated the roles of humoral factors linking muscle to bone using orchidectomized mice with sarcopenia and osteopenia. Orchidectomy (ORX) significantly reduced muscle mass, grip strength, and trabecular bone mineral density (BMD) in mice. Among the myokines examined, ORX only significantly reduced fibronectin type III domain-containing 5 (Fndc5) mRNA levels in both the soleus and gastrocnemius muscles of mice. In simple regression analyses, Fndc5 mRNA levels in the soleus muscle positively correlated with trabecular BMD, but not cortical BMD. The administration of irisin, a product of Fndc5, significantly protected against the decrease induced in trabecular BMD, but not muscle mass, by androgen deficiency in mice. In conclusion, the present results demonstrated that androgen deficiency decreases the expression of irisin in the skeletal muscle of mice. Irisin may be involved in muscle/bone relationships negatively affected by androgen deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.