ArticleNeuroImage. Clinical2019
Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury.Frontiers in neuroscience · 2026Pooled it
- Increased prevalence of depressive symptoms and stress in patients with chronic bothersome tinnitus during the COVID-19 pandemic.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions.The Laryngoscope · 2025Article
- Acceptance and Tinnitus Handicap in Chronic Tinnitus: Associations With Sleep Quality and Depression-A Cross-Sectional Study.Brain and behavior · 2025Article
- Effect of Topical Intra-Auricular Lidocaine on Tinnitus: A Randomized Double-Blind Placebo-Controlled Study.International archives of otorhinolaryngology · 2025Article
- Neuroanatomical Insights: Convergence and Divergence of Tinnitus with Normal or Mild Hearing Loss.Biomedicines · 2025Article
- Can Residual Inhibition Predict the Success of Sound Enrichment Treatment for Tinnitus?Brain and behavior · 2024Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank.BJPsych open · 2024Article
- Graph analysis based on SCN reveals novel neuroanatomical targets related to tinnitus distress.Frontiers in neuroscience · 2024Article
- The neuroanatomical hallmarks of chronic tinnitus in comorbidity with pure-tone hearing loss.Brain structure & function · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.The Journal of physiology · 2023Article
- Tinnitus and Influencing Comorbidities.Laryngo- rhino- otologie · 2023Review
- Tinnitus and Multimodal Cortical Interaction.Laryngo- rhino- otologie · 2023Article
- The Comorbidity of Depression and Anxiety Symptoms in Tinnitus Sufferers: A Network Analysis.Brain sciences · 2023Article
- Role of insula and its subregions in progression from recent onset to chronic idiopathic tinnitus.Brain communications · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic tinnitus has been associated with brain structural changes in both the auditory system as well as limbic system. While there is considerable inconsistency across brain structural findings, growing evidence suggests that distress and other non-auditory symptoms modulate effects. In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution structural magnetic resonance imaging (MRI) scans from a total of 125 subjects: 59 patients with bilateral chronic tinnitus (29 with a co-morbid psychiatric condition, 30 without), 40 healthy controls and 26 psychiatric controls with depression/anxiety disorders (without tinnitus). Voxel-based morphometry with the CAT12 software package was used to analyse data. First, we analysed data based on a 2 × 2 factorial design (tinnitus; psychiatric co-morbidity), showing trend-level effects for tinnitus in ROI analyses of the anterior cingulate cortex and superior/transverse temporal gyri, and for voxel-based analysis in the left parahippocampal cortex. Multiple regression analyses showed that the parahippocampal finding was mostly predicted by tinnitus rather than (dimensional) psychopathology ratings. Comparing only low-distress tinnitus patients (independent of co-morbid conditions) with healthy controls also showed reduced left parahippocampal grey matter. Our findings demonstrate that depression and anxiety (not only subjective distress) are major modulators of brain structural effects in tinnitus, calling for a stronger consideration of psychopathology in future neurobiological and clinical studies of tinnitus.
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