Evidence map›Paper›PMID 31494286›Full record

ArticleNeurobiology of disease2019

Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease.

Chiung-Chu Chen, Chien-Hung Yeh, Hsiao-Lung Chan, Ya-Ju Chang, Po-Hsun Tu, Chih-Hua Yeh, Chin-Song Lu, Petra Fischer, Gerd Tinkhauser, Huiling Tan and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
  2. Review
  3. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  4. Article
  5. Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Chiung-Chu ChenDivision of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: neurozoe@gmail.com.
Chien-Hung YehDivision of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan; Medical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, United Kingdom.
Hsiao-Lung ChanNeuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Electrical Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan.
Ya-Ju ChangNeuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Po-Hsun TuSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Chih-Hua YehSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neuroradiology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Chin-Song LuDivision of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; Professor Lu Neurological Clinic, Taoyuan, Taiwan.
Petra FischerMedical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, United Kingdom.
Gerd TinkhauserMedical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, United Kingdom; Department of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
Huiling TanMedical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, United Kingdom.
Peter BrownMedical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, United Kingdom.
Chang Gung University · TWJohn Radcliffe Hospital · GBChang Gung Memorial Hospital · TWUniversity of Bern · CH

Funding

Medical Research Council MC_UU_12024/1Medical Research Council MR/P012272/1
6 · The paper itself

Abstract

Freezing of gait (FOG) is a disabling clinical phenomenon often found in patients with advanced Parkinson's disease (PD). FOG impairs motor function, causes falls and leads to loss of independence. Whereas dual tasking that distracts patients' attention precipitates FOG, auditory or visual cues ameliorate this phenomenon. The pathophysiology of FOG remains unclear. Previous studies suggest that the basal ganglia are involved in the generation of FOG. Investigation of the modulation of neuronal activities within basal ganglia structures during walking is warranted. To this end, we recorded local field potentials (LFP) from the subthalamic nucleus (STN) while PD patients performed single-task gait (ST) or walked while dual-tasking (DT). An index of FOG (iFOG) derived from trunk accelerometry was used as an objective measure to differentiate FOG-vulnerable gait from normal gait. Two spectral activities recorded from the STN region were associated with vulnerability to freezing. Greater LFP power in the low beta (15-21 Hz) and theta (5-8 Hz) bands were noted during periods of vulnerable gait in both ST and DT states. Whereas the elevation of low beta activities was distributed across STN, the increase in theta activity was focal and found in ventral STN and/or substantia nigra (SNr) in ST. The results demonstrate that low beta and theta band oscillations within the STN area occur during gait susceptible to freezing in PD. They also add to the evidence that narrow band ~18 Hz activity may be linked to FOG.

Indexed as

AgedDeep Brain StimulationFemaleGait Disorders, NeurologicHumansMaleMiddle AgedParkinson DiseaseSubthalamic NucleusFOGLocal field potentials (LFPs)Parkinson's diseaseSubthalamic nucleus

Identifiers

PMID31494286
PMCPMC6764839
OpenAlexW2971601388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.