ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2019
Oral immunotherapy for multiple foods in a pediatric allergy clinic setting.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Peanut oral immunotherapy at a single academic medical center using a volume-based approach with store-purchased peanut products.The journal of allergy and clinical immunology. Global · 2026Article
- Designing an Incremental Egg Oral Immunotherapy Protocol: A Strategic Approach with Safety as a Priority.Journal of asthma and allergy · 2026Article
- The epidemiology of multifood allergy in the United States: A population-based study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Update on clinical research for food allergy treatment.Frontiers in allergy · 2023Review
- Patient selection for milk and egg ladders using a food ladder safety checklist.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Mechanisms of oral immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Review
- Weighing the benefits and risks of oral immunotherapy in clinical practice.Allergy and asthma proceedings · 2021Article
- Successful Milk Oral Immunotherapy Promotes Generation of Casein-Specific CD137Frontiers in immunology · 2021Article
- Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate.Frontiers in immunology · 2021Review
- Oral Immunotherapy in Children: Clinical Considerations and Practical Management.Journal of asthma and allergy · 2021Review
- Strategies for Mast Cell Inhibition in Food Allergy.The Yale journal of biology and medicine · 2020Review
- Food Allergy Management at School in the Era of Immunotherapy.Current allergy and asthma reports · 2020Review
- CSACI guidelines for the ethical, evidence-based and patient-oriented clinical practice of oral immunotherapy in IgE-mediated food allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe increasing incidence of pediatric food allergy results in significant health care burden and family stress. Oral immunotherapy (OIT) can induce tolerance to peanut, milk, and egg. OIT for other foods, particularly multiple foods simultaneously, has not been thoroughly studied.
objectiveTo summarize our experience with OIT for multiple foods in a pediatric allergy clinic setting.
methodsMedical records were reviewed for patients undergoing OIT for multiple foods. Methods and outcomes of OIT were summarized. Outcomes were analyzed for correlation with baseline food allergen skin prick tests (SPTs) and specific IgE (sIgE) test results.
resultsForty-five patients aged 1.5 to 18 years undertook OIT for up to 12 foods, including peanut, tree nuts, seeds, legumes, and egg. At the time of review, 35 patients were receiving daily maintenance dosing, 4 had completed OIT and were continuing to eat their foods 3 times weekly, and 6 had stopped OIT because of anxiety, inconvenience, or allergy symptoms. A total of 49% of patients had reactions during the up-dosing process, mostly oral itching (33%), perioral hives (40%), and abdominal pain (35%). There was no correlation of baseline skin prick test (SPT) and sIgE test results with reaction threshold for baseline food challenge, lowest dose causing reactions during up-dosing, or time to reach maintenance. Higher baseline sIgE level but not baseline SPT result was associated with an increased number of allergic reactions during OIT. Baseline SPT correlated with stopping OIT.
conclusionA similar approach to that used for peanut OIT can be taken for nonpeanut foods and for multiple foods simultaneously. High baseline allergy test results are not a contraindication to OIT.
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