ArticleBMC pediatrics2019
Kawasaki disease in infants less than one year of age: an Italian cohort from a single center.
Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Anakinra for intravenous immunoglobulin-resistant Kawasaki disease: a systematic literature review.RMD open · 2026Pooled it
- Access to Care and Therapy for Kawasaki Disease in Morocco: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey.Pediatric cardiology · 2026Article
- Pre-IVIG echocardiography enables targeted treatment in infants younger than 6 months with Kawasaki Disease : Echocardiography-based risk stratification in young infants with Kawasaki Disease.European journal of pediatrics · 2026Article
- Incomplete Kawasaki Disease Presenting With Coronary Artery Aneurysms in a 2.5-Month-Old Infant: A Case Report.Cureus · 2026Article
- Coronary artery abnormalities in Kawasaki disease with BCG site reactivation.European journal of pediatrics · 2025Article
- Anakinra for infants under six months with Kawasaki disease and coronary artery lesions: a multicenter case series and literature review.Pediatric rheumatology online journal · 2025Article
- Clinical utility of CBC-Derived inflammatory markers for predicting IVIG resistance: findings from a Korean infant Kawasaki disease cohort.Pediatric rheumatology online journal · 2025Article
- Atypical Kawasaki Disease in a 5-month-old Infant.Annals of African medicine · 2025Article
- Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician.Children (Basel, Switzerland) · 2025Review
- Risk Factors and Regression of Coronary Aneurysms in Infants With Kawasaki Disease.Cardiovascular therapeutics · 2025Article
- Case Report: Challenges in diagnosing Kawasaki disease in children under 3 months of age: a case series report.Frontiers in pediatrics · 2025Article
- Atypical Presentation of Kawasaki Disease With Coronary Artery Aneurysms in a 2.5-Month-Old Infant: A Case Report From Syria.Clinical medicine insights. Case reports · 2025Article
- Evaluating the performance of egami, kobayashi and sano scores in predicting IVIG resistance in infant kawasaki disease.BMC pediatrics · 2024Article
- Kawasaki disease involving both the nervous system and cardiovascular system: a case report and literature review.Frontiers in pediatrics · 2024Article
- Article
- A machine learning model for distinguishing Kawasaki disease from sepsis.Scientific reports · 2023Article
- Very early onset of coronary artery aneurysm in a 3-month infant with Kawasaki disease: a case report and literature review.Italian journal of pediatrics · 2023Review
- Incomplete Kawasaki Disease with Peripheral Facial Nerve Palsy and Lung Nodules: A Case Report and Literature Review.Children (Basel, Switzerland) · 2023Article
- A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease.Scientific reports · 2023Article
- Complete and incomplete Kawasaki disease: Clinical differences and coronary artery outcome from a national prospective surveillance study in Switzerland.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsFew data are currently available for Kawasaki disease (KD) below 12 months especially in Caucasians. This study aims to analyze clinical and laboratory features of KD among an Italian cohort of infants.
methodsA retrospective chart review of KD children aged less than 1 year at time of disease onset between January 2008-December 2017 was performed. Clinical data, laboratory parameters, instrumental findings, treatment and outcome were collected in a customized database.
resultsAmong 113 KD patients, 32 (28.3%) were younger than 1 year. Nineteen patients aged below 6 months, and three below 3 months. The median age was 5.7 ± 2.7 months. The mean time to diagnosis was 7 ± 3 days and was longer in the incomplete forms (8 ± 4 vs 6 ± 1 days). Conjunctival injection was present in 26 patients (81.2%); rash in 25 (78.1%); extremity changes in 18 (56.2%); mucosal changes in 13 (40.6%,) and lymphadenopathy only in 7 (21.8%). Mucosal changes were the least common features in incomplete forms (18.2%). Twenty-two patients (68.7%) had incomplete KD. Nineteen (59.4%) had cardiac involvement, of whom 13 (59.0%) had incomplete form. ESR, PCR and platelet values were higher in complete KD; especially, ESR resulted significantly higher in complete forms (80 ± 25.7 mm/h vs 50 ± 28.6 mm/h; p = 0.01). Conversely, AST level was statistically significant higher in patients with incomplete forms (95.4 ± 132.7 UI/L vs 29.8 ± 13.2 UI/L; p = 0.03). All patients received IVIG. Response was reported in 26/32 patients; 6 cases needed a second dose of IVIG and one required a dose of anakinra.
conclusionIn our cohort, incomplete disease was commonly found, resulting in delayed diagnoses and poor cardiac prognosis. Infants with incomplete KD seem to have a more severe disease and a greater predilection for coronary involvement than those with complete KD. AST was significantly higher in incomplete forms, thus AST levels might be a new finding in incomplete forms' diagnosis. Eventually, we highlight a higher resistance to IVIG treatment. To our knowledge this is the first study involving an Italian cohort of patients with KD below 12 months.
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