ArticlePediatric research2020
Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity.American journal of human biology : the official journal of the Human Biology Council · 2024Trial
- The "Burden" of Childhood Obesity on Bone Health: A Look at Prevention and Treatment.Nutrients · 2025Review
- Longitudinal Associations Between Physical Activity and Sedentary Time and Cardiorespiratory and Muscular Fitness in Preschoolers.Journal of functional morphology and kinesiology · 2024Article
- High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity.Archives of osteoporosis · 2024Article
- Effects of high-intensity interval training on lipid metabolism, tumor necrosis factor-α, and C-reactive proteinin overweight children.American journal of translational research · 2024Article
- Are serum thyroid hormone, parathormone, calcium, and vitamin D levels associated with lumbar spine degeneration? A cross-sectional observational clinical study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Inflammation, Executive Function, and Adiposity in Children With or at Risk for Obesity: A Pilot Study.Journal of pediatric psychology · 2023Article
- The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey.Archives of osteoporosis · 2023Article
- Editorial: Physical activity and fitness for the prevention and management of bone diseases.Frontiers in physiology · 2023Article
- Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.Pediatric research · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
methodsPlasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.
resultsIL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = -0.152) and TNF-α with LS BMC (β = -0.491) in the low-fitness group, while no association was found in the high-fitness group.
conclusionIL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.
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