Evidence map›Paper›PMID 31493521›Full record

ArticleExperimental gerontology2019

Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults.

Roger A Fielding, Andrew R Reeves, Ravi Jasuja, Christine Liu, Brittany B Barrett, Michael S Lustgarten

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 6 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 6 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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  6. Understanding the gut microbiota and sarcopenia: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021
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  17. Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roger A FieldingNutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA, USA. Electronic address: Roger.Fielding@Tufts.edu.
Andrew R ReevesObesity Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center (HNRCA), Tufts University, Boston, MA, USA. Electronic address: Andrew.Reeves@Tufts.edu.
Ravi JasujaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: rjasuja@partners.org.
Christine LiuNutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA, USA. Electronic address: Christine.Liu@bmc.org.
Brittany B BarrettNutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA, USA. Electronic address: Brittany.Barrett@Tufts.edu.
Michael S LustgartenNutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA, USA. Electronic address: Michael.Lustgarten@Tufts.edu.
Tufts University · USHarvard University · US

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9M
Mobility of older hemodialysis patientsK23AG057813 · NIA · STANFORD UNIVERSITY · PI LIU, CHRISTINE KEE · 2018 to 2022
$917k
Role of the gut microbiome and the serum metabolome on lean mass and physical function in older adultsK01AG050700 · NIA · TUFTS UNIVERSITY BOSTON · PI LUSTGARTEN, MICHAEL S · 2016 to 2019
$483k
NIA NIH HHS K01 AG050700NIA NIH HHS K23 AG057813NIA NIH HHS P30 AG031679
6 · The paper itself

Abstract

Evidence in support of a gut-muscle axis has been reported in rodents, but studies in older adult humans are limited. Accordingly, the primary goals of the present study were to compare gut microbiome composition in older adults that differed in terms of the percentage of whole body lean mass and physical functioning (high-functioning, HF, n = 18; low-functioning, LF, n = 11), and to evaluate the causative role of the gut microbiome on these variables by transferring fecal samples from older adults into germ-free mice. Family-level Prevotellaceae, genus-level Prevotella and Barnesiella, and the bacterial species Barnesiella intestinihominis were higher in HF older adults at the initial study visit, at a 1-month follow-up visit, in HF human fecal donors, and in HF-colonized mice, when compared with their LF counterparts. Grip strength was significantly increased by 6.4% in HF-, when compared with LF-colonized mice. In contrast, despite significant differences for the percentage of whole body lean mass and physical functioning when comparing the human fecal donors, the percentage of whole body lean mass and treadmill endurance capacity were not different when comparing human microbiome-containing mice. In sum, these data suggest a role for gut bacteria on the maintenance of muscle strength, but argue against a role for gut bacteria on the maintenance of the percentage of whole body lean mass or endurance capacity, findings that collectively add to elucidation of the gut-muscle axis in older adults.

Indexed as

AgedAged, 80 and overAnimalsBacteroidetesBody CompositionExerciseFecal Microbiota TransplantationFecesFemaleGastrointestinal MicrobiomeHumansMaleMuscle, SkeletalMuscle StrengthPrevotellaSarcopeniaAgingBody compositionMicrobiomeMuscle strengthPhysical functionSarcopenia

Identifiers

PMID31493521
PMCPMC6823114
OpenAlexW2972062895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.