ArticleJournal of the American Geriatrics Society2019
Subclinical Cardiovascular Disease and Fall Risk in Older Adults: Results From the Atherosclerosis Risk in Communities Study.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Cardiovascular Disorders and Falls Among Older Adults: A Systematic Review and Meta-Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- A novel multistep approach to standardize the reported risk factors for in-hospital falls: a proof-of-concept study.Frontiers in public health · 2024Pooled it
- Development of a web platform for predicting fall risk in cardiovascular patients using machine learning.Scientific reports · 2026Article
- Health economics evaluation of screening for sarcopenia among community-dwelling older persons.BMC public health · 2025Article
- Cardiovascular Pharmacotherapy and Falls in Old People: Risks and Prevention-An Observational Case-Control Study.Journal of clinical medicine · 2025Article
- Associations between sleep parameters and falls among older adults with and without cardiovascular disease: Evidence from the China Health and Retirement Longitudinal Study (CHARLS).Geriatrics & gerontology international · 2025Article
- The impact of depression and cardiovascular disease on fall risk in type 2 diabetes mellitus: a gender and sleep status analysis.Frontiers in public health · 2025Article
- Association of motor index scores with fall incidence among community-dwelling older people.BMC geriatrics · 2022Article
- Geriatric Cardiology: Coming of Age.JACC. Advances · 2022Article
- Impact of cardiovascular evaluations and interventions on fall risk in older adults: a protocol for a scoping review and evidence map.BMJ open · 2022Article
- Associations of High-Sensitivity Troponin and Natriuretic Peptide Levels With Serious Adverse Events in SPRINT.Journal of the American Heart Association · 2022Article
- Relationship between high-sensitivity cardiac troponin T, B-type natriuretic peptide, and physical function in patients with heart failure.ESC heart failure · 2021Article
- Falls, Subclinical Cardiovascular Disease, and a Nonagenarian's Sage Advice.Journal of the American Geriatrics Society · 2019Article
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9 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesFalls are frequent and often devastating events among older adults. Cardiovascular disease (CVD) is associated with greater fall risk; however, it is unknown if pathways that contribute to CVD, such as subclinical myocardial damage or wall strain, are related to future falls. We hypothesized that elevations in high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), measured in older adults, would be associated with greater fall risk.
designProspective cohort study. SETTING AND
participantsAtherosclerosis Risk in Communities Study participants without known coronary heart disease, heart failure, or stroke. MEASUREMENTS: We measured hs-cTnT or NT-proBNP in 2011 to 2013. Falls were identified from hospital discharge International Classification of Diseases, Ninth Revision (ICD-9), codes or Centers for Medicare and Medicaid Services claims. We used Poisson models adjusted for age, sex, and race/study center to quantify fall rates across approximate quartiles of hs-cTnT (less than 8, 8-10, 11-16, and 17 or greater ng/L) and NT-proBNP (less than 75, 75-124, 125-274, and 275 or greater pg/mL). We used Cox models to determine the association of cardiac markers with fall risk, adjusted for age, sex, race/center, and multiple fall risk factors.
resultsAmong 3973 participants (mean age = 76 ± 5 years, 62% women, 22% black), 457 had a subsequent fall during a median follow-up of 4.5 years. Incidence rates across quartiles of hs-cTnT and NT-proBNP were 17.1, 20.0, 26.2, and 36.4 per 1000 person-years and 12.8, 22.2, 28.7, and 48.4 per 1000 person-years, respectively. Comparing highest vs lowest quartiles of either hs-cTnT or NT-proBNP demonstrated a greater than two-fold higher fall risk, with hazard ratios of 2.17 (95% confidence interval {CI} = 1.60-2.95) and 2.34 (95% CI = 1.73-3.16), respectively. In a joint model, the relationships of hs-cTnT and NT-proBNP with falls were significant and independent.
conclusionSubclinical elevations of cardiac damage and wall strain were each associated with a higher fall risk in older adults. Further research is needed to determine whether interventions that lower hs-cTnT or NT-proBNP also lower fall risk. J Am Geriatr Soc 67:1795-1802, 2019.
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