ArticleJournal of veterinary internal medicine2019
Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Serum multi-element profiling and a Metallobalance index for noninvasive differentiation of canine prostatic adenocarcinoma: a pilot case-control study.Frontiers in veterinary science · 2026Article
- Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research.Environment & health (Washington, D.C.) · 2024Review
- Comprehensive analysis of copper-metabolism-related genes about prognosis and immune microenvironment in osteosarcoma.Scientific reports · 2023Article
- Relationships between the Content of Micro- and Macroelements in Animal Samples and Diseases of Different Etiologies.Animals : an open access journal from MDPI · 2023Article
- Copper in cancer: from limiting nutrient to therapeutic target.Frontiers in oncology · 2023Review
- Hepatocellular Carcinoma in a Free-Ranging Three-Toed Sloth (Animals : an open access journal from MDPI · 2022Article
- Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology.Journal of veterinary internal medicine · 2021Article
- Zinc in Dog Nutrition, Health and Disease: A Review.Animals : an open access journal from MDPI · 2021Review
- Selenium and Dogs: A Systematic Review.Animals : an open access journal from MDPI · 2021Review
- Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs.Animals : an open access journal from MDPI · 2020Article
- Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma.Journal of veterinary internal medicine · 2019Article
- Research progress in cuproptosis in liver cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHepatocellular carcinoma (HCC) is the most common primary liver tumor in dogs. Abnormalities in hepatic copper, iron, zinc, and selenium concentrations increase risk for HCC development in other species, but trace mineral concentrations have not been evaluated in dogs with HCC.
objectivesTo investigate hepatic trace mineral concentrations in dogs with HCC. ANIMALS: Archived liver specimens from 85 dogs with HCC and 85 control dogs.
methodsRetrospective case-control study. A histopathology database was searched to identify dogs with HCC (test population) and an age-matched control population. Demographic information was retrieved, and H&E and rhodanine stained slides were reviewed for all cases. Copper, iron, zinc, and selenium concentrations were determined in noncancerous liver tissues (test and control population) and in HCC tissues (test population) using inductively coupled plasma mass spectrometry.
resultsHepatic copper concentrations (non-neoplastic hepatic tissue) were greater in test population dogs (median, IQR; 294.9 μg/g, 233.5-475.9 μg/g) than in control dogs (202.8 μg/g, 135.0-295.3 μg/g; P < .001). Hepatic zinc concentrations in test (132.1 μg/g,108.6-163.2 μg/g) and control dogs (151.5 μg/g, 117.1-184.5 μg/g) also were different (P = .03). Within test population dogs, all trace mineral concentrations were decreased in the HCC tissue as compared to the non-neoplastic hepatic tissue (all P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Hepatic copper accumulation and other abnormalities in hepatic trace mineral concentrations could be involved in the pathogenesis of HCC in some dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.