Evidence map›Paper›PMID 31493329›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2019

Effects of Left Gastric Artery Ligation Versus Sleeve Gastrectomy on Obesity-Induced Adipose Tissue Macrophage Infiltration and Inflammation in Diet-Induced Obese Rats.

Yi Shen, Yang Liu, Shao-Qiu Zheng, Jiang Han, Er-Li Pei, Zhi-Hong Li, Xiao-Yun Xie, Zhi-Qiang Li, Ming Luo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yi ShenDepartment of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China (mainland).
Yang LiuDepartment of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China (mainland).
Shao-Qiu ZhengDepartment of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China (mainland).
Jiang HanDivision of General Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, China (mainland).
Er-Li PeiDepartment of General Surgery, Yangpu Hospital Affiliated to Shanghai Tongji University School of Medicine, Shanghai, China (mainland).
Zhi-Hong LiDivision of General Surgery, Pudong New Area District Zhoupu Hospital, Shanghai, China (mainland).
Xiao-Yun XieDepartment of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China (mainland).
Zhi-Qiang LiDepartment of Neurology, Shanxi Academy of Medical Sciences, Shanxi Dayi Hospital, Taiyuan, Shanxi, China (mainland).
Ming LuoDepartment of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China (mainland).
Tongji University · CNPudong New Area People's Hospital · CNShanghai Tenth People's Hospital · CNShanxi Academy of Medical Sciences · CNYangpu Hospital of Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Bariatric procedures such as left gastric artery ligation (LGAL) and sleeve gastrectomy (SG) have emerged as important procedures for treating morbid obesity. In this study, we compared the effects of LGAL vs. SG on obesity-induced adipose tissue macrophage infiltration and inflammation in diet-induced obese rats. MATERIAL AND METHODS Sprague-Dawley (SD) rats were fed a high-fat diet (HFD) for 16 weeks to induce obesity. SG, GLAL, or corresponding sham surgeries were performed in anesthetized rats. Inflammatory factor expression in serum and epididymal and retroperitoneal adipose tissues were analyzed 4 weeks after surgery. Macrophage infiltration and phenotype transformation were also assessed with Western blot analysis and immunofluorescence. RESULTS Both LGAL and SG strongly attenuated high-fat diet (HFD)-induced fat accumulation in retroperitoneal and epididymal tissues. The expressions of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 were downregulated after LGAL and after SG by promoting activation of M2 macrophages, despite continued exposure to HFD. Furthermore, both LGAL and SG resulted in increased macrophage infiltration, but did not contribute to phenotype transformation of macrophages to M1. CONCLUSIONS LGAL and SG both reduced fat accumulation caused by HFD feeding. Therapies designed to ameliorate the inflammatory response by promoting activation of M2 macrophages may be valuable.

Indexed as

Diet, High-FatGastrectomyAdipose TissueAnimalsEpididymisGastric ArteryInflammationInflammation MediatorsInsulin Receptor Substrate ProteinsLigationMacrophagesMaleNF-kappa BObesityPhosphorylationProto-Oncogene Proteins c-aktInflammation MediatorsInsulin Receptor Substrate ProteinsIrs1 protein, ratNF-kappa BProto-Oncogene Proteins c-akt

Identifiers

PMID31493329
PMCPMC6752093
OpenAlexW2972007887

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.